Lessons learned from natural infection: focusing on the design of protective T cell vaccines for HIV/AIDS

被引：23

作者：

Ahlers, Jeffrey D. ^{[1
]}

Belyakov, Igor M. ^{[2
]}

机构：

[1] NIAID, NIH, Bethesda, MD 20817 USA

[2] Midwest Res Inst, Frederick, MD 21702 USA

来源：

TRENDS IN IMMUNOLOGY | 2010年 / 31卷 / 03期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; VIRAL REPLICATION CAPACITY; IMMUNE ESCAPE; MUCOSAL IMMUNIZATION; LYMPHOCYTE EPITOPES; ELITE CONTROLLERS; HIV-INFECTION; HIGH-AVIDITY; V-BETA; RESPONSES;

D O I：

10.1016/j.it.2009.12.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8(+) cytotoxic T lymphocyte (CTL) responses are crucial in establishing the control of persistent virus infections. Population studies of HIV-1-infected individuals suggest that CD8(+) CTL responses targeting epitopes that take the greatest toll on virus replication are instrumental in immune control. A major question for vaccine design is whether incorporating epitopes responsible for controlling a persistent virus will translate into protection from natural infection or serve solely as a fail-safe mechanism to prevent overt disease in infected individuals. Here, we discuss qualitative parameters of the CD8(+) CTL response and mechanisms operative in the control of persistent virus infections and suggest new strategies for design and delivery of HIV vaccines.

引用

页码：120 / 130

页数：11

共 116 条

[61] Magnitude and phenotype of cellular immune responses elicited by recombinant adenovirus vectors and heterologous prime-boost regimens in rhesus monkeys [J].

Liu, Jinyan ;

Ewald, Bonnie A. ;

Lynch, Diana M. ;

Denholtz, Matthew ;

Abbink, Peter ;

Lemckert, Angelique A. C. ;

Carville, Angela ;

Mansfield, Keith G. ;

Havenga, Menzo J. ;

Goudsmit, Jaap ;

Barouch, Dan H. .

JOURNAL OF VIROLOGY, 2008, 82 (10) :4844-4852

[62] Modulation of DNA vaccine-elicited CD8+ T-lymphocyte epitope immunodominance hierarchies [J].

Liu, Jinyan ;

Ewald, Bonnie A. ;

Lynch, Diana M. ;

Nanda, Anjali ;

Surnida, Shawn M. ;

Barouch, Dan H. .

JOURNAL OF VIROLOGY, 2006, 80 (24) :11991-11997

[63] Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys [J].

Liu, Jinyan ;

O'Brien, Kara L. ;

Lynch, Diana M. ;

Simmons, Nathaniel L. ;

La Porte, Annalena ;

Riggs, Ambryice M. ;

Abbink, Peter ;

Coffey, Rory T. ;

Grandpre, Lauren E. ;

Seaman, Michael S. ;

Landucci, Gary ;

Forthal, Donald N. ;

Montefiori, David C. ;

Carville, Angela ;

Mansfield, Keith G. ;

Havenga, Menzo J. ;

Pau, Maria G. ;

Goudsmit, Jaap ;

Barouch, Dan H. .

NATURE, 2009, 457 (7225) :87-91

[64] Mamu-B*08-positive macaques control simian immunodeficiency virus replication [J].

Loffredo, John T. ;

Maxwell, Jess ;

Qi, Ying ;

Glidden, Chrystal E. ;

Borchardt, Gretta J. ;

Soma, Taeko ;

Bean, Alex T. ;

Beal, Dominic R. ;

Wilson, Nancy A. ;

Rehrauer, William M. ;

Lifson, Jeffrey D. ;

Carrington, Mary ;

Watkins, David I. .

JOURNAL OF VIROLOGY, 2007, 81 (16) :8827-8832

[65] The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape [J].

Loffredo, John T. ;

Burwitz, Benjamin J. ;

Rakasz, Eva G. ;

Spencer, Sean P. ;

Stephany, Jason J. ;

Vela, Juan Pablo Giraldo ;

Martin, Sarah R. ;

Reed, Jason ;

Piaskowski, Shari M. ;

Furlott, Jessica ;

Weisgrau, Kim L. ;

Rodrigues, Denise S. ;

Soma, Taeko ;

Napoe, Gnankang ;

Friedrich, Thomas C. ;

Wilson, Nancy A. ;

Kallas, Esper G. ;

Watkins, David I. .

JOURNAL OF VIROLOGY, 2007, 81 (06) :2624-2634

[66] Vaccination and timing influence SIV immune escape viral dynamics in vivo [J].

Loh, Liyen ;

Petravic, Janka ;

Batten, C. Jane ;

Davenport, Miles P. ;

Kent, Stephen J. .

PLOS PATHOGENS, 2008, 4 (01) :0027-0037

[67] Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques [J].

Maness, Nicholas J. ;

Yant, Levi J. ;

Chung, Chungwon ;

Loffredo, John T. ;

Friedrich, Thomas C. ;

Piaskowski, Shari M. ;

Furlott, Jessica ;

May, Gemma E. ;

Soma, Taeko ;

Leon, Enrique J. ;

Wilson, Nancy A. ;

Piontkivska, Helen ;

Hughes, Austin L. ;

Sidney, John ;

Sette, Alessandro ;

Watkins, David I. .

JOURNAL OF VIROLOGY, 2008, 82 (11) :5245-5254

[68] Contribution of T-cell receptor repertoire breadth to the dominance of epitope-specific CD8+ T-lymphocyte responses [J].

Manuel, Edwin R. ;

Charini, William A. ;

Sen, Pritha ;

Peyerl, Fred W. ;

Kuroda, Marcelo J. ;

Schmitz, Jorn E. ;

Autissier, Patrick ;

Sheeter, Dennis A. ;

Torbett, Bruce E. ;

Letvin, Norman L. .

JOURNAL OF VIROLOGY, 2006, 80 (24) :12032-12040

[69] Novel strategies to eliminate persistent viral infections [J].

Martinic, Marianne M. ;

von Herrath, Matthias G. .

TRENDS IN IMMUNOLOGY, 2008, 29 (03) :116-124

[70] Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge [J].

Mattapallil, Joseph J. ;

Douek, Daniel C. ;

Buckler-White, Alicia ;

Montefiori, David ;

Letvin, Norman L. ;

Nabel, Gary J. ;

Roederer, Mario .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (06) :1533-1541

← 2 3 4 5 6 7 8 9 10 11 →