Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery

被引：134

作者：

Canelas, Dorian A. ^{[1
]}

Herlihy, Kevin P. ^{[1
]}

DeSimone, Joseph M. ^{[1
,2
,3
,4
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[4] N Carolina State Univ, Dept Chem Engn, Raleigh, NC 27695 USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2009年 / 1卷 / 04期

关键词：

ENZYMATICALLY DEGRADABLE BONDS; RESOLUTION SOFT LITHOGRAPHY; IN-VIVO; GOLD NANOPARTICLES; CELLULAR UPTAKE; GENE; POLYMERS; MICROPARTICLES; SURFACE; VACCINES;

D O I：

10.1002/wnan.40

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

This review discusses rational design of particles for use as therapeutic vectors and diagnostic imaging agent carriers. The emerging importance of both particle size and shape is considered, and the adaptation and modification of soft lithography methods to produce nanoparticles are highlighted. To this end, studies utilizing particles made via a process called Particle Replication In Non-wetting Templates are discussed. In addition, insights gained into therapeutic cargo and imaging agent delivery from related types of polymer-based carriers are considered. (C) 2009 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2009 1 391-404

引用

页码：391 / 404

页数：14

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