Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

被引:92
作者
Li, Meirong [1 ,2 ,3 ,4 ,5 ]
Jiang, Yufeng [7 ]
Hou, Qian [1 ,2 ,3 ,4 ,5 ]
Zhao, Yali [6 ]
Zhong, Lingzhi [1 ,2 ,3 ,4 ,5 ]
Fu, Xiaobing [1 ,2 ,3 ,4 ,5 ]
机构
[1] PLA Gen Hosp & PLA Med Coll, Res Ctr Tissue Repair & Regenerat, Med Innovat Res Div, Beijing, Peoples R China
[2] PLA Gen Hosp & PLA Med Coll, Med Ctr 4, Beijing, Peoples R China
[3] PLA Key Lab Tissue Repair & Regenerat Med, Beijing, Peoples R China
[4] Beijing Key Res Lab Skin Injury Repair & Regenera, Beijing, Peoples R China
[5] Chinese Acad Med Sci, Res Unit Trauma Care Tissue Repair & Regenerat, 2019RU051, Beijing, Peoples R China
[6] Hainan Hosp, Chinese PLA Gen Hosp, Cent Lab, Trauma Treatment Ctr, Sanya, Peoples R China
[7] PLA Strateg Support Force Characterist Med Ctr, Wound Repairing Dept, Beijing 100101, Peoples R China
关键词
Mesenchymal stem cell; Pre-activation; Therapeutic potential; Individualized MSCs therapy; LEVEL LASER THERAPY; LOW-OXYGEN TENSION; PEROXIDE-INDUCED APOPTOSIS; NF-KAPPA-B; BONE-MARROW; STROMAL CELLS; ADIPOSE-TISSUE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; INTERFERON-GAMMA;
D O I
10.1186/s13287-022-02822-2
中图分类号
Q813 [细胞工程];
学科分类号
100113 [医学细胞生物学];
摘要
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising approach targeting a variety of intractable diseases due to remarkable multiple effect of MSCs, such as multilineage differentiation, immunomodulatory property, and pro-regenerative capacity. However, poor engraftment, low survival rate of transplanted MSC, and impaired donor-MSC potency under host age/disease result in unsatisfactory therapeutic outcomes. Enhancement strategies, including genetic manipulation, pre-activation, and modification of culture method, have been investigated to generate highly functional MSC, and approaches for MSC pre-activation are highlighted. In this review, we summarized the current approaches of MSC pre-activation and further classified, analysed the scientific principles and main characteristics of these manipulations, and described the pros and cons of individual pre-activation strategies. We also discuss the specialized tactics to solve the challenges in this promising field so that it improves MSC therapeutic functions to serve patients better.
引用
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页数:21
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