Phase-enhanced selective ion ejection in an orbitrap mass spectrometer

被引：14

作者：

Hu, Qizhi ^{[1
]}

Cooks, R. Graham ^{[1
]}

Noll, Robert J. ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2007年 / 18卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.jasms.2007.02.004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The mass resolution achieved in selective ion isolation using resonance excitation is usually limited by the frequency resolution of the ac waveform and by unintended off-resonance excitation. A new method of phase-enhanced selective ion ejection based on broadband dipolar excitation and ion ejection applicable to the Orbitrap is described and shown to allow an isolation resolution of 28,400. The method is calculated to be able to provide a mass resolution for ion ejection of up to 100,000.

引用

收藏

页码：980 / 983

页数：4

相关论文

共 12 条

[1] Interfacing the orbitrap mass analyzer to an electrospray ion source [J].

Hardman, M ;

Makarov, AA .

ANALYTICAL CHEMISTRY, 2003, 75 (07) :1699-1705

[2] MASS-SPECIFIC SELECTION OF IONS IN FOURIER-TRANSFORM ION-CYCLOTRON RESONANCE MASS-SPECTROMETRY - UNINTENTIONAL OFF-RESONANCE CYCLOTRON EXCITATION OF SELECTED IONS [J].

HECK, AJR ;

DEKONING, LJ ;

PINKSE, FA ;

NIBBERING, NMM .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1991, 5 (09) :406-414

[3] Resonant ac dipolar excitation for ion motion control in the orbitrap mass analyzer [J].

Hu, Q ;

Makarov, AA ;

Cooks, RG ;

Noll, RJ .

JOURNAL OF PHYSICAL CHEMISTRY A, 2006, 110 (08) :2682-2689

[4] The Orbitrap: a new mass spectrometer [J].

Hu, QZ ;

Noll, RJ ;

Li, HY ;

Makarov, A ;

Hardman, M ;

Cooks, RG .

JOURNAL OF MASS SPECTROMETRY, 2005, 40 (04) :430-443

[5] Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer [J].

Makarov, A ;

Denisov, E ;

Kholomeev, A ;

Baischun, W ;

Lange, O ;

Strupat, K ;

Horning, S .

ANALYTICAL CHEMISTRY, 2006, 78 (07) :2113-2120

[6] Electrostatic axially harmonic orbital trapping: A high-performance technique of mass analysis [J].

Makarov, A .

ANALYTICAL CHEMISTRY, 2000, 72 (06) :1156-1162

[7] Dynamic range of mass accuracy in LTQ Orbitrap hybrid mass spectrometer [J].

Makarov, Alexander ;

Denisov, Eduard ;

Lange, Oliver ;

Horning, Stevan .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2006, 17 (07) :977-982

[8]

McLuckey, 1988, MASS SPECTROMETRY MA

[9]

NOLL RJ, 2006, P 54 ASMS C MASS SPE

[10]

Senko MW, 1996, RAPID COMMUN MASS SP, V10, P1839, DOI 10.1002/(SICI)1097-0231(199611)10:14<1839::AID-RCM718>3.0.CO