Ca2+ regulation and gene expression in normal brain aging

被引：170

作者：

Toescu, EC ^{[1
]}

Verkhratsky, A

Landfield, PW

机构：

[1] Univ Birmingham, Dept Physiol, Div Med Sci, Birmingham B15 2TT, W Midlands, England

[2] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[3] Univ Kentucky, Coll Med, Dept Mol & Biomed Pharmacol, Lexington, KY 40536 USA

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 10期

关键词：

D O I：

10.1016/j.tins.2004.07.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca2+ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca2+ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.

引用

页码：614 / 620

页数：7

共 69 条

[1] Calcium signalling: Dynamics, homeostasis and remodelling [J].

Berridge, MJ ;

Bootman, MD ;

Roderick, HL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (07) :517-529

[2] The endoplasmic reticulum: a multifunctional signaling organelle [J].

Berridge, MJ .

CELL CALCIUM, 2002, 32 (5-6) :235-249

[3] Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses [J].

Blalock, EM ;

Geddes, JW ;

Chen, KC ;

Porter, NM ;

Markesbery, WR ;

Landfield, PW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (07) :2173-2178

[4]

Blalock EM, 2003, J NEUROSCI, V23, P3807

[5] Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons [J].

Clodfelter, GV ;

Porter, NM ;

Landfield, PW ;

Thibault, O .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 447 (2-3) :189-200

[6] Calcium, a signaling molecule in the endoplasmic reticulum? [J].

Corbett, EF ;

Michalak, M .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (07) :307-311

[7] Mitochondria and aging: a role for the permeability transition? [J].

Crompton, M .

AGING CELL, 2004, 3 (01) :3-6

[8] Increased phosphorylation of the neuronal L-type Ca2+ channel Cav1.2 during aging [J].

Davare, MA ;

Hell, JW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) :16018-16023

[9] Energy thresholds in brain mitochondria - Potential involvement in neurodegeneration [J].

Davey, GP ;

Peuchen, S ;

Clark, JB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (21) :12753-12757

[10] Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus [J].

Disterhoft, JF ;

Thompson, LT ;

Moyer, JR ;

Mogul, DJ .

LIFE SCIENCES, 1996, 59 (5-6) :413-420

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