Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies

被引：8

作者：

Ijdo, JW ^{[1
]}

Zhang, Y ^{[1
]}

Anderson, ML ^{[1
]}

Goldberg, D ^{[1
]}

Fikrig, E ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Rheumatol Sect,Lab Clin Invest 610, New Haven, CT 06520 USA

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 1998年 / 5卷 / 01期

关键词：

D O I：

10.1128/CDLI.5.1.118-120.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe a patient with human granulocytic ehrlichiosis (HGE), a diagnosis confirmed by PCR and immunoblot analysis. Unexpectedly, immunoglobulin G (IgG) directed towards an 80-kDa ehrlichial antigen (without detectable IgM) was present in the patient's serum in the first week of illness. Lyme disease immunoblots were reactive for IgG (but not IgM), a result indicative of prior exposure to the Lyme disease spirochete. Amino-terminal sequencing revealed that the 80-kDa ehrlichial antigen was an HSP-70 homolog similar to Borrelia burgdorferi HSP-70. We conclude that antibodies against B. burgdorferi HSP-70 may cross-react with the ehrlichial heat shock protein and that this possibility must be considered when serologic test results for HGE and Lyme disease are interpreted.

引用

页码：118 / 120

页数：3

共 18 条

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