Pd-Catalyzed Intramolecular Acylation of Aryl Bromides via C-H Functionalization: A Highly Efficient Synthesis of Benzocyclobutenones

被引：117

作者：

Alvarez-Bercedo, Paula ^{[1
]}

Flores-Gaspar, Areli ^{[1
]}

Correa, Arkaitz ^{[1
]}

Martin, Ruben ^{[1
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 02期

关键词：

KETENE SILYL ACETAL; RING EXPANSION; PALLADIUM CATALYSIS; AROMATIC-ALDEHYDES; KETONES; DERIVATIVES; ANNULATION; COMPLEXES; INSERTION; BENZYNE;

D O I：

10.1021/ja909811t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new catalyst system for the intramolecular acylation of aldehydes with aryl bromides via C-H functionalization is described. The transformation is distinguished by a remarkable functional group tolerance and hence allows for the synthesis of a wide variety of highly functionalized benzocyclobutenones with a diverse set of substitution patterns from simple and easily accessible precursors.

引用

页码：466 / +

页数：3

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