Nickel- and Copper-Catalyzed Direct Alkynylation of Azoles and Polyfluoroarenes with Terminal Alkynes under O2 or Atmospheric Conditions

被引：178

作者：

Matsuyama, Naoto ^{[1
]}

Kitahara, Masanori ^{[1
]}

Hirano, Koji ^{[1
]}

Satoh, Tetsuya ^{[1
]}

Miura, Masahiro ^{[1
]}

机构：

[1] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 10期

关键词：

C-H BONDS; GACL3-CATALYZED ORTHO-ETHYNYLATION; SONOGASHIRA REACTION; OXYGEN COMPLEXES; PALLADIUM; HETEROCYCLES; ARYLATION; 1,3,4-OXADIAZOLES; BROMIDES; OXIDANT;

D O I：

10.1021/ol100699g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct C-H alkynylation of azoles with terminal alkynes proceeds efficiently under a nickel/O-2 catalytic system. On the other hand, a copper/air catalyst enables the coupling of polyfluoroarenes with terminal alkynes. These catalyses provide new accesses to arylacetylenes through the formal direct Sonogashira coupling.

引用

页码：2358 / 2361

页数：4

共 35 条

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