Polymer enlarged oxazaborolidines in a membrane reactor: enhancing effectivity by retention of the homogeneous catalyst

被引：82

作者：

Giffels, G ^{[1
]}

Beliczey, J ^{[1
]}

Felder, M ^{[1
]}

Kragl, U ^{[1
]}

机构：

[1] Forschungszentrum Julich, Inst Biotechnol, D-52425 Julich, Germany

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0957-4166(98)00011-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Polymer enlarged oxazaborolidines that are homogeneously soluble were used as catalysts for the enantioselective reduction of ketones in a continuously operated membrane reactor equipped with a nanofiltration membrane. The amount of chiral product per mole of catalyst could be enhanced from 10 up to 560 moles (=0.18 mol% catalyst). The chiral alcohols are obtained in good to excellent ee and space-time yield (up to 99% ee and 1.4 kg/[L(reactor volume) x day)]. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：691 / 696

页数：6

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