1,4-dichloro- and 1,4-dibromo-2-butenes as substrates for Cu-catalyzed asymmetric allylic substitution

被引：41

作者：

Falciola, Caroline A. ^{[1
]}

Alexakis, Alexandre ^{[1
]}

机构：

[1] Univ Geneva, Dept Chim Organ, CH-1211 Geneva 4, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 15期

关键词：

alkylation; allylic compounds; asymmetric catalysis; copper; nucleophilic substitution;

D O I：

10.1002/anie.200604963

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Cu at the AAA meeting: Difunctionalized allylic substrates can undergo Cu-catalyzed asymmetric allylic alkylation (AAA) reactions with high enantioselectivities. The products have a functional group that remains for further transformation through substitution with a nucleophile (Nu) or electrophile (E) with conservation of optical purity (see scheme; TC = thiophene carboxylate). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2619 / 2622

页数：4

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