Distribution of TiO2 particles in the olfactory bulb of mice after nasal inhalation using microbeam SRXRF mapping techniques

被引：44

作者：

Wang, J. X. ^{[1
]}

Chen, C. Y.

Yu, H. W.

Sun, J.

Li, B.

Li, Y. F.

Gao, Y. X.

He, W.

Huang, Y. Y.

Chai, Z. F.

Zhao, Y. L.

Deng, X. Y.

Sun, H. F.

机构：

[1] Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Synchrotron Radiat Facil Lab, Inst High Energy Phys, Beijing 100049, Peoples R China

[4] Shenzhen Univ, Inst Nucl Technol, Shenzhen 518060, Peoples R China

[5] Peking Univ, Dept Biol Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2007年 / 272卷 / 03期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1007/s10967-007-0617-z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The characterization of different sized TiO2 (25 nm, 80 nm, and 155 nm) was carried out by transmission electron microscopy (TEM) and the micro-distributions of TiO2 in the olfactory bulb of mice after nasal inhalation were investigated by microbeam SRXRF mapping techniques. The results show that TiO2 particles can be translocated to the olfactory bulb through the olfactory nerve system after inhalation. The distributions of Fe, Cu, and Zn in the olfactory bulb were also studied.

引用

收藏

页码：527 / 531

页数：5

相关论文

共 18 条

[1] Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles [J].

Bermudez, E ;

Mangum, JB ;

Asgharian, B ;

Wong, BA ;

Reverdy, EE ;

Janszen, DB ;

Hext, PM ;

Warheit, DB ;

Everitt, JI .

TOXICOLOGICAL SCIENCES, 2002, 70 (01) :86-97

[2] Mortality among workers employed in the titanium dioxide production industry in Europe [J].

Boffetta, P ;

Soutar, A ;

Cherrie, JW ;

Granath, F ;

Andersen, A ;

Anttila, A ;

Blettner, M ;

Gaborieau, V ;

Klug, SJ ;

Langard, S ;

Luce, D ;

Merletti, F ;

Miller, B ;

Mirabelli, D ;

Pukkala, E ;

Adami, HO ;

Weiderpass, E .

CANCER CAUSES & CONTROL, 2004, 15 (07) :697-706

[3] Chronic inflammation and tumor formation in rats after intratracheal instillation of high doses of coal dusts, titanium dioxides, and quartz [J].

Borm, PJA ;

Höhr, D ;

Steinfartz, Y ;

Zeitträger, I ;

Albrecht, C .

INHALATION TOXICOLOGY, 2000, 12 :225-231

[4] Ultrafine (nanometre) particle mediated lung injury [J].

Donaldson, K ;

Li, XY ;

MacNee, W .

JOURNAL OF AEROSOL SCIENCE, 1998, 29 (5-6) :553-560

[5] PULMONARY RETENTION OF ULTRAFINE AND FINE PARTICLES IN RATS [J].

FERIN, J ;

OBERDORSTER, G ;

PENNEY, DP .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1992, 6 (05) :535-542

[6] Combination of synchrotron radiation X-ray fluorescence with isoelectric focusing for study of metalloprotein distribution in cytosol of hepatocellular carcinoma and surrounding normal tissues [J].

Gao, YX ;

Liu, YB ;

Chen, CY ;

Li, B ;

He, W ;

Huang, YY ;

Chai, ZF .

JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 2005, 20 (05) :473-475

[7]

HUANG YE, 2001, IND SCI TECHNOL, V18, P7

[8] Trace element load in cancer and normal lung tissue [J].

Kubala-Kukus, A ;

Braziewicz, J ;

Banas, D ;

Majewska, U ;

Gózdz, S ;

Urbaniak, A .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1999, 150 (1-4) :193-199

[9] Pulmonary response to toner, TiO2 and crystalline silica upon chronic inhalation exposure in Syrian golden hamsters [J].

Muhle, H ;

Bellmann, B ;

Creutzenberg, O ;

Koch, W ;

Dasenbrock, C ;

Ernst, H ;

Mohr, U ;

Morrow, P ;

Mermelstein, R .

INHALATION TOXICOLOGY, 1998, 10 (07) :699-729

[10] Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese [J].

Normandin, L ;

Beaupré, LA ;

Salehi, F ;

St-Pierre, A ;

Kennedy, G ;

Mergler, D ;

Butterworth, RE ;

Philippe, S ;

Zayed, J .

NEUROTOXICOLOGY, 2004, 25 (03) :433-441