Synthesis and antiviral activity of C-5 substituted β-D- and β-L-D4T analogues

被引：6

作者：

Delbederi, Z

Fossey, C

Fontaine, G

Benzaria, S

Gavriliu, D

Ciurea, A

Lelong, B

Ladurée, D

Aubertin, AM

Kirn, A

机构：

[1] UFR Sci Pharmaceut, Ctr Etudes & Rech Medicament Normandie, F-14032 Caen, France

[2] INSERM, F-67000 Strasbourg, France

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2000年 / 19卷 / 09期

关键词：

D O I：

10.1080/15257770008033853

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of beta -D-2',3'-didehydro-2',3'-dideoxy-nucleosides bearing a tether attached at the C-5 position and their beta -L-counterparts was synthesized. Their inhibitory activities against human immunodeficiency virus (HIV) were investigated and compared to establish relationship(s) between compound structure and their antiviral activity. No significant activity was observed for beta -D- and beta -L-modified nucleosides respectively 7a-c and 14a-c, but 7d and 14d exhibited a weak activity against HIV-1.

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页码：1441 / 1461

页数：21

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