Stem cell paracrine actions and tissue regeneration

被引：705

作者：

Baraniak, Priya R. ^{[1
,2
]}

McDevitt, Todd C. ^{[1
,2
,3
]}

机构：

[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[2] Emory Univ, Atlanta, GA 30322 USA

[3] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA

来源：

REGENERATIVE MEDICINE | 2010年 / 5卷 / 01期

关键词：

cancer; immune modulation; paracrine actions; stem cells; tissue regeneration; trophic factors; MARROW STROMAL CELLS; VERSUS-HOST-DISEASE; ENDOTHELIAL GROWTH-FACTOR; HUMAN BONE-MARROW; SMALL-INTESTINAL SUBMUCOSA; IMPROVE CARDIAC-FUNCTION; ARTERY OCCLUSION MODEL; CANCER GENE-THERAPY; SPINAL-CORD-INJURY; EXTRACELLULAR-MATRIX;

D O I：

10.2217/RME.09.74

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Stem cells have emerged as a key element of regenerative medicine therapies due to their inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries. A recent paradigm shift has emerged suggesting that the beneficial effects of stem cells may not be restricted to cell restoration alone, but also due to their transient paracrine actions. Stem cells can secrete potent combinations of trophic factors that modulate the molecular composition of the environment to evoke responses from resident cells. Based on this new insight, current research directions include efforts to elucidate, augment and harness stem cell paracrine mechanisms for tissue regeneration. This article discusses the existing studies on stem/progenitor cell trophic factor production, implications for tissue regeneration and cancer therapies, and development of novel strategies to use stem cell paracrine delivery for regenerative medicine.

引用

页码：121 / 143

页数：23

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