Stem cell paracrine actions and tissue regeneration

被引:705
作者
Baraniak, Priya R. [1 ,2 ]
McDevitt, Todd C. [1 ,2 ,3 ]
机构
[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
[2] Emory Univ, Atlanta, GA 30322 USA
[3] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA
关键词
cancer; immune modulation; paracrine actions; stem cells; tissue regeneration; trophic factors; MARROW STROMAL CELLS; VERSUS-HOST-DISEASE; ENDOTHELIAL GROWTH-FACTOR; HUMAN BONE-MARROW; SMALL-INTESTINAL SUBMUCOSA; IMPROVE CARDIAC-FUNCTION; ARTERY OCCLUSION MODEL; CANCER GENE-THERAPY; SPINAL-CORD-INJURY; EXTRACELLULAR-MATRIX;
D O I
10.2217/RME.09.74
中图分类号
Q813 [细胞工程];
学科分类号
100113 [医学细胞生物学];
摘要
Stem cells have emerged as a key element of regenerative medicine therapies due to their inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries. A recent paradigm shift has emerged suggesting that the beneficial effects of stem cells may not be restricted to cell restoration alone, but also due to their transient paracrine actions. Stem cells can secrete potent combinations of trophic factors that modulate the molecular composition of the environment to evoke responses from resident cells. Based on this new insight, current research directions include efforts to elucidate, augment and harness stem cell paracrine mechanisms for tissue regeneration. This article discusses the existing studies on stem/progenitor cell trophic factor production, implications for tissue regeneration and cancer therapies, and development of novel strategies to use stem cell paracrine delivery for regenerative medicine.
引用
收藏
页码:121 / 143
页数:23
相关论文
共 236 条
[51]
Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor [J].
Duan, HF ;
Wu, CT ;
Wu, DL ;
Lu, Y ;
Liu, HJ ;
Ha, XQ ;
Zhang, QW ;
Wang, H ;
Jia, XX ;
Wang, LS .
MOLECULAR THERAPY, 2003, 8 (03) :467-474
[52]
Heat shock induces the synthesis of the inflammatory mediator leukotriene B4 in human pulp cells [J].
Eberhard, J ;
Zahl, A ;
Dommisch, H ;
Winter, J ;
Acil, Y ;
Jepsen, S .
INTERNATIONAL ENDODONTIC JOURNAL, 2005, 38 (12) :882-888
[53]
Expression and biological role of laminin-1 [J].
Ekblom, P ;
Lonai, P ;
Talts, JF .
MATRIX BIOLOGY, 2003, 22 (01) :35-47
[54]
Laser-induced thermal stress and the heat shock response in neural cells [J].
Emohare, O ;
Hafez, MI ;
Sandison, A ;
Coombs, RRH ;
McCarthy, ID .
ACTA ORTHOPAEDICA SCANDINAVICA, 2004, 75 (05) :610-617
[55]
IFN-γ and TNF-α differentially regulate immunomodulation by murine mesenchymal stem cells [J].
English, Karen ;
Barry, Frank P. ;
Field-Corbett, Ciara P. ;
Mahon, Bernard P. .
IMMUNOLOGY LETTERS, 2007, 110 (02) :91-100
[56]
Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity [J].
Erkan, Mert ;
Kleeff, Joerg ;
Gorbachevski, Andre ;
Reiser, Carolin ;
Mitkus, Tomas ;
Esposito, Irene ;
Giese, Thomas ;
Buechler, Markus W. ;
Giese, Nathalia A. ;
Friess, Helmut .
GASTROENTEROLOGY, 2007, 132 (04) :1447-1464
[57]
Secretome From Mesenchymal Stem Cells Induces Angiogenesis Via Cyr61 [J].
Estrada, Rosendo ;
Li, Na ;
Sarojini, Harshini ;
An, Jin ;
Lee, Menq-Jer ;
Wang, Eugenia .
JOURNAL OF CELLULAR PHYSIOLOGY, 2009, 219 (03) :563-571
[58]
Die Hard: Are Cancer Stem Cells the Bruce Willises of Tumor Biology? [J].
Fabian, Akos ;
Barok, Mark ;
Vereb, Gyoergy ;
Szoellosi, Janos .
CYTOMETRY PART A, 2009, 75A (01) :67-74
[59]
STROMAL CELLS RESPONSIBLE FOR TRANSFERRING MICROENVIRONMENT OF HEMATOPOIETIC TISSUES - CLONING INVITRO AND RETRANSPLANTATION INVIVO [J].
FRIEDENSTEIN, AJ ;
CHAILAKHYAN, RK ;
LATSINIK, NV ;
PANASYUK, AF ;
KEILISSB.IV .
TRANSPLANTATION, 1974, 17 (04) :331-340
[60]
Mesenchymal stem cells and skin wound repair and regeneration: possibilities and questions [J].
Fu, Xiaobing ;
Li, Haihong .
CELL AND TISSUE RESEARCH, 2009, 335 (02) :317-321