Macrosphelide, a novel inhibitor of cell-cell adhesion molecule .2. Physicochemical properties and structural elucidation

被引：85

作者：

Takamatsu, S

Kim, YP

Hayashi, M

Hiraoka, H

Natori, M

Komiyama, K

Omura, S

机构：

[1] KITASATO INST, MINATO KU, TOKYO 108, JAPAN

[2] NIHON UNIV, COLL AGR & VET MED, FUJISAWA, KANAGAWA 252, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 01期

关键词：

D O I：

10.7164/antibiotics.49.95

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New anticell-adherence compounds, macrosphelides A and B, were isolated from the fermentation broth of Microsphaeropsis sp. FO-5050, and their structures were elucidated by spectroscopic methods and by chemical transformations. Macrosphelides A (M.W. 342, C16H22O8) and B (M.W. 340, C16H20O8) with three esters in their molecules were classified as 16-membered macrocyclic compounds. Macrosphelide B was found to be a corresponding oxidative product of macrosphelide A at the C-14 position.

引用

页码：95 / 98

页数：4

共 10 条

[1]

[Anonymous], MACROLIDE ANTIBIOTIC

[2] LEUKOCYTE-ENDOTHELIAL CELL RECOGNITION - 3 (OR MORE) STEPS TO SPECIFICITY AND DIVERSITY [J].