NEW INHIBITORS OF MELANOGENESIS, OH-3984 K1 AND K2 .2. PHYSICOCHEMICAL PROPERTIES AND STRUCTURAL ELUCIDATION

被引：13

作者：

TAKAMATSU, S

RHO, MC

HAYASHI, M

KOMIYAMA, K

TANAKA, H

OMURA, S

IMOKAWA, G

机构：

[1] KITASATO UNIV,KITASATO INST,5-9-1 SHIROKANE,MINATO KU,TOKYO 108,JAPAN

[2] KITASATO UNIV,SCH PHARMACEUT SCI,TOKYO 108,JAPAN

[3] KAO CORP,BIOL SCI LABS,HAGA,TOCHIGI 32134,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 10期

关键词：

D O I：

10.7164/antibiotics.46.1526

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New melanin synthesis inhibitors, OH-3984 K1 and K2, were isolated from the fermentation broth of Streptomyces sp. OH-3984, and their structures were elucidated by spectroscopic methods and by chemical transformations. OH-3984 K1 (M.W.: 306; C18H26O4) and K2 (M.W.: 308; C18H28O4) have unique gamma-lactone rings, both of which correspond to oxidative products derived from C1-O-14 cleavage of the 14-membered lactone group.

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页码：1526 / 1529

页数：4

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