Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients

被引:119
作者
Ljungman, Per [1 ,2 ]
Hakki, Morgan [3 ]
Boeckh, Michael [4 ,5 ]
机构
[1] Karolinska Inst, Dept Med Huddinge, Div Hematol, S-14186 Stockholm, Sweden
[2] Karolinska Univ Hosp, Dept Hematol, S-14186 Huddinge, Sweden
[3] Oregon Hlth & Sci Univ, Div Infect Dis, Portland, OR 97201 USA
[4] Univ Washington, Seattle, WA 98195 USA
[5] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Inst, Seattle, WA 98109 USA
关键词
Adoptive immunotherapy; Antiviral therapy; Cytomegalovirus; Hematopoietic stem cell transplantation; BONE-MARROW-TRANSPLANT; POLYMERASE-CHAIN-REACTION; VERSUS-HOST-DISEASE; INTRAVENOUS IMMUNE GLOBULIN; CORD BLOOD TRANSPLANTATION; PREEMPTIVE ANTIVIRAL THERAPY; CHRONIC MYELOID-LEUKEMIA; PERIPHERAL-BLOOD; RISK-FACTORS; CMV INFECTION;
D O I
10.1016/j.idc.2010.01.008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This article examines the clinical manifestations of and risk factors for cytomegalovirus (CMV). Prevention of CMV infection and disease are also explored. Antiviral resistance and management of CMV are examined.
引用
收藏
页码:319 / +
页数:20
相关论文
共 164 条
[71]  
JACOBSEN N, 1990, BONE MARROW TRANSPL, V5, P413
[72]   Diagnostic Performance of the Cytomegalovirus (CMV) Antigenemia Assay in Patients with CMV Gastrointestinal Disease [J].
Jang, Eun-Young ;
Park, Seong Yeon ;
Lee, Eun Jung ;
Song, Eun Hee ;
Chong, Yong Pill ;
Lee, Sang-Oh ;
Choi, Sang-Ho ;
Woo, Jun Hee ;
Kim, Yang Soo ;
Kim, Sung-Han .
CLINICAL INFECTIOUS DISEASES, 2009, 48 (12) :E121-E124
[73]   Risk factors in pediatric stem cell transplantation for leukemia [J].
Jernberg, ÅG ;
Remberger, M ;
Ringdén, O ;
Winiarski, J .
PEDIATRIC TRANSPLANTATION, 2004, 8 (05) :464-474
[74]  
JONJIC S, 1990, J VIROL, V64, P5457
[75]   Differential initiation of innate immune responses induced by human cytomegalovirus entry into fibroblast cells [J].
Juckem, Laura K. ;
Boehme, Karl W. ;
Feire, Adam L. ;
Compton, Teresa .
JOURNAL OF IMMUNOLOGY, 2008, 180 (07) :4965-4977
[76]   Incidence and outcome of cytomegalovirus infections following nonmyeloablative compared with myeloablative allogeneic stem cell transplantation, a matched control study [J].
Junghanss, C ;
Boeckh, M ;
Carter, RA ;
Sandmaier, BM ;
Maris, MB ;
Maloney, DG ;
Chauncey, T ;
McSweeney, PA ;
Little, MT ;
Corey, L ;
Storb, R .
BLOOD, 2002, 99 (06) :1978-1985
[77]   Target structures of the CD8+-T-cell response to human cytomegalovirus:: the 72-kilodalton major immediate-early protein revisited [J].
Kern, F ;
Surel, IP ;
Faulhaber, N ;
Frömmel, C ;
Schneider-Mergener, J ;
Schönemann, C ;
Reinke, P ;
Volk, HD .
JOURNAL OF VIROLOGY, 1999, 73 (10) :8179-8184
[78]   Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals [J].
Kern, F ;
Bunde, T ;
Faulhaber, N ;
Kiecker, F ;
Khatamzas, E ;
Rudawski, IM ;
Pruss, A ;
Gratama, JW ;
Volkmer-Engert, R ;
Ewert, R ;
Reinke, P ;
Volk, HD ;
Picker, LJ .
JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (12) :1709-1716
[79]   Identification of cytomegalovirus-specific cytotoxic T lymphocytes in vitro is greatly enhanced by the use of recombinant virus lacking the US2 to US11 region or modified vaccinia virus Ankara expressing individual viral genes [J].
Khan, N ;
Bruton, R ;
Taylor, GS ;
Cobbold, M ;
Jones, TR ;
Rickinson, AB ;
Moss, PAH .
JOURNAL OF VIROLOGY, 2005, 79 (05) :2869-2879
[80]   Herpesvirus-specific CD8 T cell immunity in old age: Cytomegalovirus impairs the response to a coresident EBV infection [J].
Khan, N ;
Hislop, A ;
Gudgeon, N ;
Cobbold, M ;
Khanna, R ;
Nayak, L ;
Rickinson, AB ;
Moss, PAH .
JOURNAL OF IMMUNOLOGY, 2004, 173 (12) :7481-7489