Genetics of anxiety disorders

被引：36

作者：

Arnold P.D. ^{[1
]}

Zai G. ^{[1
]}

Richter M.A. ^{[1
]}

机构：

[1] Anxiety Disorders Clinic, Centre for Addiction/Mental Health, University of Toronto, Toronto, Ont. M5T 1R8

来源：

Current Psychiatry Reports | 2004年 / 6卷 / 4期

基金：

英国医学研究理事会;

关键词：

Anxiety Disorder; Panic Disorder; Panic Disorder; Harm Avoidance; Myelin Oligodendrocyte Glycoprotein;

D O I：

10.1007/s11920-004-0073-1

中图分类号：

学科分类号：

摘要：

There is considerable evidence that genetic determinants play a major role in the etiology of anxiety. Investigations into susceptibility genes for anxiety are well underway, particularly for panic disorder and obsessive-compulsive disorder and more broadly defined anxiety-related traits, such as neuroticism and harm avoidance. This review will discuss some of the core issues related to diagnosis and molecular genetic methodology, followed by a review of recent molecular genetic findings for anxiety. The authors will attempt to highlight the numerous convergent and exciting findings. Given the rapid acceleration in knowledge of the human genome, a more definitive understanding of the genetic roots of these complex conditions may be anticipated in the relatively near future. Copyright © 2004 by Current Science Inc.

引用

页码：243 / 254

页数：11

共 115 条

[1]

Hettema J.M., Neale M.C., Kendler K.S., A review and meta-analysis of the genetic epidemiology of anxiety disorders, Am. J. Psychiatry, 158, pp. 1568-1578, (2001)

[2]

Merikangas K.R., Lieb R., Wittchen H.U., Avenevoli S., Family and high-risk studies of social anxiety disorder, Acta Psychiatr. Scand. Suppl., 417, pp. 28-37, (2003)

[3]

Black D.W., Gaffney G.R., Schlosser S., Gabel J., Children of parents with obsessive-compulsive disorder: A 2-year follow-up study, Acta Psychiatr. Scand., 107, pp. 305-313, (2003)

[4]

Kendler K.S., Aggen S.H., Jacobson K.C., Neale M.C., Does the level of family dysfunction moderate the impact of genetic factors on the personality trait of neuroticism?, Psychol. Med., 33, pp. 817-825, (2003)

[5]

Page G.P., George V., Go R.C., Et al., Are we there yet?" Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits, Am. J. Hum. Genet., 73, pp. 711-719, (2003)

[6]

Hudson J.I., Mangweth B., Pope Jr. H.G., Et al., Family study of affective spectrum disorder, Arch. Gen. Psychiatry, 60, pp. 170-177, (2003)

[7]

Kendler K.S., Prescott C.A., Myers J., Neale M.C., The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women, Arch. Gen. Psychiatry, 60, pp. 929-937, (2003)

[8]

Gorwood P., Generalized anxiety disorder and major depressive disorder comorbidity: An example of genetic pleiotropy?, Eur. Psychiatry, 19, pp. 27-33, (2004)

[9]

Gottesman I.I., Gould T.D., The endophenotype concept in psychiatry: Etymology and strategic intentions, Am. J. Psychiatry, 160, pp. 636-645, (2003)

[10]

Alsobrook J., Leckman J., Goodman W., Et al., Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores, Am. J. Med. Genet., 88, pp. 669-675, (1999)

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