Genetics of anxiety disorders

被引：36

作者：

Arnold P.D. ^{[1
]}

Zai G. ^{[1
]}

Richter M.A. ^{[1
]}

机构：

[1] Anxiety Disorders Clinic, Centre for Addiction/Mental Health, University of Toronto, Toronto, Ont. M5T 1R8

来源：

Current Psychiatry Reports | 2004年 / 6卷 / 4期

基金：

英国医学研究理事会;

关键词：

Anxiety Disorder; Panic Disorder; Panic Disorder; Harm Avoidance; Myelin Oligodendrocyte Glycoprotein;

D O I：

10.1007/s11920-004-0073-1

中图分类号：

学科分类号：

摘要：

There is considerable evidence that genetic determinants play a major role in the etiology of anxiety. Investigations into susceptibility genes for anxiety are well underway, particularly for panic disorder and obsessive-compulsive disorder and more broadly defined anxiety-related traits, such as neuroticism and harm avoidance. This review will discuss some of the core issues related to diagnosis and molecular genetic methodology, followed by a review of recent molecular genetic findings for anxiety. The authors will attempt to highlight the numerous convergent and exciting findings. Given the rapid acceleration in knowledge of the human genome, a more definitive understanding of the genetic roots of these complex conditions may be anticipated in the relatively near future. Copyright © 2004 by Current Science Inc.

引用

页码：243 / 254

页数：11

共 115 条

[81]

Swedo S.E., Leonard H.L., Rapoport J.L., The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: Separating fact from fiction, Pediatrics, 113, pp. 907-911, (2004)

[82]

Johns T.G., Bernard C.C., Binding of complement component Clq to myelin oligodendrocyte glycoprotein: A novel mechanism for regulating CNS inflammation, Mol. Immunol., 34, pp. 33-38, (1997)

[83]

Zai G., Bezchlibnyk Y.B., Richter M.A., Et al., Myelin oligodendrocyte glycoprotein (MOG) gene associated with obsessive-compulsive disorder, Am. J. Med. Genet., (2004)

[84]

Urraca N., Camarena B., Gomez-Caudillo L., Et al., Mu opioid receptor gene as a candidate for the study of obsessive compulsive disorder with and without tics, Am. J. Med. Genet., 127 B, pp. 94-96, (2004)

[85]

Gelernter J., Page G.P., Stein M.B., Woods S.W., Genome-wide linkage scan for loci predisposing to social phobia: Evidence for a chromosome 16 risk locus, Am. J. Psychiatry, 161, pp. 59-66, (2004)

[86]

Gelernter J., Page G.P., Bonvicini K., Et al., A chromosome 14 risk locus for simple phobia: Results from a genomewide linkage scan, Mol. Psychiatry, 8, pp. 71-82, (2003)

[87]

Flint J., Corley R., DeFries J.C., Et al., A simple genetic basis for a complex psychological trait in laboratory mice, Science, 269, pp. 1432-1435, (1995)

[88]

Tadic A., Rujescu D., Szegedi A., Et al., Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression, Am. J. Med. Genet., 117 B, pp. 1-6, (2003)

[89]

Lawford B.R., Mc D.Y.R., Noble E.P., Et al., D2 dopamine receptor gene polymorphism: Paroxetine and social functioning in posttraumatic stress disorder, Eur. Neuropsychopharmacol., 13, pp. 313-320, (2003)

[90]

Fullerton J., Cubin M., Tiwari H., Et al., Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism, Am. J. Hum. Genet., 72, pp. 879-890, (2003)

← 3 4 5 6 7 8 9 10 11 12 →