Aeroallergens and pollinosis: Molecular and immunological characteristics of cloned pollen allergens

被引：23

作者：

De Weerd N.A. ^{[1
]}

Bhalla P.L. ^{[1
]}

Singh M.B. ^{[1
]}

机构：

[1] Plant Molecular Biology Laboratory, Institute of Land and Food Resources, University of Melbourne, Parkville

来源：

Aerobiologia | 2002年 / 18卷 / 2期

关键词：

Allergens; Cloning; Hay fever; Pollen allergy;

D O I：

10.1023/A:1020685718591

中图分类号：

学科分类号：

摘要：

Affecting almost twenty percent of the population in industrialized countries, allergic diseases such as asthma and seasonal rhinitis result from the development of immediate hypersensitivity to otherwise innocuous components of the environment. Pollen, the male gametophyte of flowering plant species, is one of the most predominant sources of environmental allergens, and a significant cause of allergic diseases. This review discusses the nature of pollen proteins as allergens, their effect on the human immune system and their mode of environmental transmission, including effects of the interaction between pollen aeroallergens and air pollution. The influence of cross-reactive pollen allergens to the incidence of food sensitivities is also discussed. Flowering plant species that possess allergenic pollen, identified with allergens cloned from these species, are also discussed.

引用

页码：87 / 106

页数：19

共 154 条

[131]

Obispo T.M., Melero J.A., Carpizo J.A., Carreira J., Lombardero M., The main allergen of Olea europaea (Ole e I) is also present in other species of the Oleaceae family, Clin Exp Allergy, 23, pp. 311-316, (1993)

[132]

Ohno N., Ide T., Sakaguchi M., Inouye S., Saito S., Common antigenicity between Japanese cedar (Cryptomeria japonica) pollen and Japanese cypress (Chamaecyparis obtusa) pollen. II. Determination of the cross-reacting T-cell epitope of cry j 1 and cha o 1 in mice, Immunology, 99, pp. 630-634, (2000)

[133]

Okada T., Swoboda I., Bhalla P.L., Toriyama K., Singh M.B., Engineering of hypoallergenic mutants of the Brassica pollen allergen, Bra r 1, for immunotherapy, FEBS Lett, 434, pp. 255-260, (1998)

[134]

Ong E.K., Griffith I.J., Knox R.B., Singh M.B., Cloning of a cDNA encoding a group-V (group-IX) allergen isoform from rye-grass pollen that demonstrates specific antigenic immunoreactivity, Gene, 134, pp. 235-240, (1993)

[135]

Ong E.K., Knox R.B., Singh M.B., Mapping of the antigenic and allergenic epitopes of Lol p VB using gene fragmentation, Mol Immunol, 32, pp. 295-302, (1995)

[136]

Ortega N., Quiralte J., Blanco C., Castillo R., Alvarez M.J., Carrillo T., Tobacco allergy: Demonstration of cross-reactivity with other members of Solanaceae family and mugwort pollen, Ann Allergy Asthma Immunol, 82, pp. 194-197, (1999)

[137]

Park H.S., Hong C.S., Choi H.J., Hahm K.S., Identification and partial purification of pollen allergens from Artemisia princeps, Yonsei Med J, 30, pp. 346-354, (1989)

[138]

Park J.W., Ko S.H., Kim C.W., Jeoung B.J., Hong C.S., Identification and characterization of the major allergen of the Humulus japonicus pollen, Clin Exp Allergy, 29, pp. 1080-1086, (1999)

[139]

Perez M., Ishioka G.Y., Walker L.E., Chesnut R.W., cDNA cloning and immunological characterization of the rye grass allergen Lol p I, J Biol Chem, 265, pp. 16210-16215, (1990)

[140]

Petersen A., Bufe A., Schlaak M., Becker W.M., Characterization of the allergen group VI in timothy grass pollen (Phl p 6). I. Immunological and biochemical studies, Int Arch Allergy Immunol, 108, pp. 49-54, (1995)

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