Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression

被引：43

作者：

Chen, Lei ^{[1
,2
]}

Li, Zong-yang ^{[2
]}

Xu, Sui-yi ^{[2
]}

Zhang, Xie-jun ^{[2
]}

Zhang, Yuan ^{[2
]}

Luo, Kun ^{[3
]}

Li, Wei-ping ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou 510275, Guangdong, Peoples R China

[2] Shenzhen Univ, Affiliated Hosp 1, Dept Neurosurg, Shenzhen Key Lab Neurosurg,Shenzhen Peoples Hosp, Shenzhen 518035, Peoples R China

[3] Shandong Univ, Sch Med, Jinan 250100, Peoples R China

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2016年 / 36卷 / 01期

关键词：

Glioma; miR-107; Angiogenesis; HBMVEC; VEGF; PROLIFERATION; MECHANISMS; MIGRATION; MICRORNAS; INVASION; GROWTH; CELLS;

D O I：

10.1007/s10571-015-0225-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs can function as oncogenes or tumor suppressors in glioma. Previously, we showed that miR-107 inhibits glioma cell proliferation, migration, and invasion. Since tumor growth and invasion are closely related to angiogenesis, we further examined the role of miR-107 in glioma angiogenesis. In a co-culture of glioma cells and human brain microvascular endothelial cells (HBMVEC), overexpression of miR-107 in glioma cells led to the inhibition of HBMVEC proliferation, migration, and tube formation ability. ELISA, RT-PCR, and western blot assays revealed that upregulation of miR-107 in glioma cells inhibits VEGF expression. Our findings collectively support the critical involvement of miR-107 in glioma cell angiogenesis and highlight its potential as a therapeutic target for glioma.

引用

页码：113 / 120

页数：8

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