SYNTHESIS AND BIOACTIVITIES OF HETEROCYCLIC LIPIDS AS PAF ANTAGONISTS .1.

被引：6

作者：

CHUNG, SK

BAN, SH

KIM, SH

KIM, BE

WOO, SH

机构：

[1] RES INST IND SCI & TECHNOL,POHANG 790784,SOUTH KOREA

[2] ABBOTT LABS,DIV PHARMACEUT PROD,IMMUNNOSCI RES AREA,ABBOTT PK,IL 60064

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 10期

关键词：

D O I：

10.1016/0960-894X(95)00173-Q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conformationally constrained analogues of platelet activating factor incorporating various combinations of a lipophile and a pyridine-like heterocycle via hydrogen bond accepters such as ether and/or carbamate linked to a suitable core group such as 1,1-bis(hydroxymethyl)cycloalkane and 3,3-bis(hydroxymethyl)-oxetane, -thietane and -azetidine skeletons have been synthesized, and are shown to be powerful and selective PAF receptor antagonists.

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页码：1091 / 1096

页数：6

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