BLINDING OF A SOLUBLE ALPHA-BETA-T-CELL RECEPTOR TO SUPERANTIGEN MAJOR HISTOCOMPATIBILITY COMPLEX LIGANDS

被引：62

作者：

KAPPLER, J

WHITE, J

KOZONO, H

CLEMENTS, J

MARRACK, P

机构：

[1] UNIV COLORADO,SCH MED,DEPT IMMUNOL,DENVER,CO 80206

[2] UNIV COLORADO,SCH MED,DEPT MED,DENVER,CO 80206

[3] UNIV COLORADO,SCH MED,DEPT BIOCHEM BIOPHYS & GENET,DENVER,CO 80206

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 18期

关键词：

BACULOVIRUS; ENTEROTOXIN;

D O I：

10.1073/pnas.91.18.8462

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The genes for the alpha and beta chains of a murine T-cell receptor were truncated just prior to the portions encoding the transmembrane regions and introduced into baculovirus by recombination. Insect cells infected with the virus secreted a soluble form of the receptor that could be purified to homogeneity. This soluble receptor reacted with a set of six monoclonal antibodies originally raised to different epitopes on the natural transmembrane-region-containing receptor and bound with appropriate specificity to a cell surface complex of the human major histocompatibility complex class II molecule DR1 with the bacterial superantigen staphylococcal enterotoxin B.

引用

收藏

页码：8462 / 8466

页数：5

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