AGE-DEPENDENT RESPONSIVENESS TO INTERLEUKIN-6 IN LYMPHOCYTES-B FROM A SYSTEMIC LUPUS ERYTHEMATOSUS-PRONE (NZB X NZW)F1 HYBRID

被引:26
作者
ALARCONRIQUELME, ME
MOLLER, G
FERNANDEZ, C
机构
[1] Department of Immunology, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm
来源
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1992年 / 62卷 / 03期
关键词
D O I
10.1016/0090-1229(92)90101-S
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The cellular mechanisms for the production of IgG anti-DNA antibodies were studied. Culture of T and B cells from old (NZB × NZW)F1 mice led to the production of IgG anti-DNA antibodies. We found that direct cell contact was partly necessary for the production of IgG anti-DNA antibodies Fixation of the T cells showed that lymphokines were largely responsible for the antibody synthesis. Antibodies to mouse interleukin-6 (IL-6) inhibited the production of these antibodies in the T-B cell coculture. Human IL-6 could induce small "resting" B cells from the old (NZB × NZW)F1 mice to produce IgG anti-DNA antibodies in a dose-dependent fashion. The response was inhibited by an anti-human IL-6 monoclonal antibody. Large or small B cells from young ( B W)F1 mice or Balb c mice were not induced by IL-6 to antibody production. Therefore, the capacity of the B W mice to produce the IgG anti-DNA antibodies correlated with the ability of the B cells to respond to IL-6 and with the age at which the mice begin to have signs of the disease. © 1992.
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收藏
页码:264 / 269
页数:6
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