POTENT EFFECTS OF LOW-LEVELS OF MHC CLASS II-ASSOCIATED INVARIANT CHAIN ON CD4(+) T-CELL DEVELOPMENT

被引:54
作者
NAUJOKAS, MF
ARNESON, LS
FINESCHI, B
PETERSON, ME
SITTERDING, S
HAMMOND, AT
REILLY, C
LO, D
MILLER, J
机构
[1] UNIV CHICAGO, DEPT PHARMACOL & PHYSIOL SCI, CHICAGO, IL 60637 USA
[2] Scripps Res Inst, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
关键词
D O I
10.1016/1074-7613(95)90120-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Invariant chain (li)-negative mice exhibit defects in MHC class II assembly and transport that results in reduced levels of surface class II, altered antigen presentation, and inefficient positive selection of CD4(+) T cells. Many CD4(+) T cells that do mature in ii-negative mice express a cell surface phenotype consistent with aberrant positive selection or peripheral activation. Reconstitution of these mice with low levels of either the p31 or p41 form of ii does not restore transport of the bulk of class II or class II surface expression, but surprisingly does restore positive selection as measured by numbers and surface phenotype of CD4(+) T cells. Thus, an ii-dependent process, independent of effects on class II surface density, appears to be required for normal positive selection of CD4(+) T cells.
引用
收藏
页码:359 / 372
页数:14
相关论文
共 99 条
[1]   PEPTIDES IN POSITIVE AND NEGATIVE SELECTION - A DELICATE BALANCE [J].
ALLEN, PM .
CELL, 1994, 76 (04) :593-596
[2]   TRANSIENT ACCUMULATION OF NEW CLASS-II MHC MOLECULES IN A NOVEL ENDOCYTIC COMPARTMENT IN B-LYMPHOCYTES [J].
AMIGORENA, S ;
DRAKE, JR ;
WEBSTER, P ;
MELLMAN, I .
NATURE, 1994, 369 (6476) :113-120
[3]   INVARIANT CHAIN CAN FUNCTION AS A CHAPERONE PROTEIN FOR CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES [J].
ANDERSON, MS ;
MILLER, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2282-2286
[4]   ENHANCED ANTIGEN PRESENTATION IN THE ABSENCE OF THE INVARIANT CHAIN ENDOSOMAL LOCALIZATION SIGNAL [J].
ANDERSON, MS ;
SWIER, K ;
ARNESON, L ;
MILLER, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :1959-1969
[5]   EFFICIENT ENDOSOMAL LOCALIZATION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II-INVARIANT CHAIN COMPLEXES REQUIRES MULTIMERIZATION OF THE INVARIANT CHAIN TARGETING SEQUENCE [J].
ARNESON, LS ;
MILLER, J .
JOURNAL OF CELL BIOLOGY, 1995, 129 (05) :1217-1228
[6]   PEPTIDE CONTRIBUTES TO THE SPECIFICITY OF POSITIVE SELECTION OF CD8+ T-CELLS IN THE THYMUS [J].
ASHTONRICKARDT, PG ;
VANKAER, L ;
SCHUMACHER, TNM ;
PLOEGH, HL ;
TONEGAWA, S .
CELL, 1993, 73 (05) :1041-1049
[7]   EVIDENCE FOR A DIFFERENTIAL AVIDITY MODEL OF T-CELL SELECTION IN THE THYMUS [J].
ASHTONRICKARDT, PG ;
BANDEIRA, A ;
DELANEY, JR ;
VANKAER, L ;
PIRCHER, HP ;
ZINKERNAGEL, RM ;
TONEGAWA, S .
CELL, 1994, 76 (04) :651-663
[8]   REPERTOIRE-DETERMINING ROLE OF PEPTIDE IN THE POSITIVE SELECTION OF CD8+ T-CELLS [J].
ASHTONRICKARDT, PG ;
VANKAER, L ;
SCHUMACHER, TNM ;
PLOEGH, HL ;
TONEGAWA, S .
IMMUNOLOGICAL REVIEWS, 1993, 135 :157-182
[9]   A SUBSET OF CD4(+) THYMOCYTES SELECTED BY MHC CLASS-I MOLECULES [J].
BENDELAC, A ;
KILLEEN, N ;
LITTMAN, DR ;
SCHWARTZ, RH .
SCIENCE, 1994, 263 (5154) :1774-1778
[10]   CD1 RECOGNITION BY MOUSE NK1(+) T-LYMPHOCYTES [J].
BENDELAC, A ;
LANTZ, O ;
QUIMBY, ME ;
YEWDELL, JW ;
BENNINK, JR ;
BRUTKIEWICZ, RR .
SCIENCE, 1995, 268 (5212) :863-865