DIAZEPAM AND RO-15-1788 INCREASE ABSENCE EPILEPSY IN WAG/RIJ RATS CHRONICALLY EXPOSED TO DIAZEPAM

被引：9

作者：

PEETERS, BWMM ^{[1
]}

VANRIJN, CM ^{[1
]}

NUTT, DJ ^{[1
]}

TITULAER, MNG ^{[1
]}

VOSSEN, JMH ^{[1
]}

COENEN, AML ^{[1
]}

机构：

[1] SCH MED SCI BRISTOL,RECKITT & COLMAN PSYCHOPHARMACOL UNIT,BRISTOL B58 1TD,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 178卷 / 01期

关键词：

Diazepam; Epilepsy (non-convulsive); Ro; 15-1788; Tolerance; WAG/Rij inbred strain;

D O I：

10.1016/0014-2999(90)94801-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanisms underlying tolerance to benzodiazepines were investigated by injecting diazepam (5 mg/kg) twice daily for 23 days in WAG/Rij rats (an animal model for non-convulsive absence epilepsy). After this the rats received either the agonist, diazepam, or the antagonist, flumazenil (Ro 15-1788). EEG analyses showed that both compounds increased the amount of absence epilepsy-like phenomena. This suggests that repeated administration of diazepam moves the benzodiazepine receptor spectrum towards the inverse agonist end. © 1990.

引用

页码：111 / 114

页数：4

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