THE COGNITIVE PRINCIPLE CHALLENGES CLONAL SELECTION

被引：157

作者：

COHEN, IR

机构：

[1] Irun R. Cohen is at the Dept of Cell Biology, The Weizmann Institute of Science, Rehovot

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 11期

关键词：

D O I：

10.1016/0167-5699(92)90071-E

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Here, Irun Cohen argues that the clonal selection paradigm is no longer a convenient paradigm for organizing thinking about the immune system. He contends that most immunologists now investigate questions for which the clonal selection paradigm makes no provision and that one of its major tenets is contradicted by the prevalence of natural autoimmunity. Instead, be proposes a cognitive paradigm.

引用

页码：441 / 444

页数：4

共 27 条

[11]

de Mey M., 1982, COGNITIVE PARADIGM, DOI [10.1007/978-94-009-7956-7, DOI 10.1007/978-94-009-7956-7]

[12]

DENNETT DC, 1990, INTENTIONAL STANCE

[13] ALLELE-SPECIFIC MOTIFS REVEALED BY SEQUENCING OF SELF-PEPTIDES ELUTED FROM MHC MOLECULES [J].