M-CAVEOLIN, A MUSCLE-SPECIFIC CAVEOLIN-RELATED PROTEIN

被引：195

作者：

WAY, M ^{[1
]}

PARTON, RG ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB, W-6901 HEIDELBERG, GERMANY

来源：

FEBS LETTERS | 1995年 / 376卷 / 1-2期

关键词：

CAVEOLAE; MUSCLE; VIP21-CAVEOIIN; M-CAVEOLIN; MEMBRANE; C2C12;

D O I：

10.1016/0014-5793(95)01256-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caveolae, small invaginations of the plasma membrane, are a characteristic feature of many mammalian cells, The best-characterised caveolar protein is the integral membrane protein, VIP21-caveolin. We now describe a novel homologue of VIP21-caveolin, M-caveolin, which is expressed exclusively in muscle, M-caveolin was shown to be expressed in differentiated myotubes but not myoblasts, Epitope-tagged M-caveolin expressed in non-muscle cells was targetted to surface caveolae where it colocalized with endogenous VIP21-caveolin, M-caveolin may play a specialised role in the caveolae of muscle cells.

引用

页码：108 / 112

页数：5

共 37 条

[31]

SIMIONESCU M, 1991, CELL BIOL REV, V25, P5

[32] CAVEOLIN MOVES FROM CAVEOLAE TO THE GOLGI-APPARATUS IN RESPONSE TO CHOLESTEROL OXIDATION [J].