PLATELET-ADHESION ON POLYMERS HAVING PHOSPHOLIPID POLAR GROUP

被引：12

作者：

UEDA, T

ISHIHARA, K

NAKABAYASHI, N

机构：

[1] Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101

来源：

KOBUNSHI RONBUNSHU | 1991年 / 48卷 / 05期

关键词：

NONTHROMBOGENICITY; PHOSPHORYLCHOLINE; PLATELET; HYDROPHILIC; HYDROPHOBIC;

D O I：

10.1295/koron.48.289

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The effect of hydrophilic groups in hydrophilic-hydrophobic copolymers on platelets adhesion and activation was studied by microsphere-column method. Copolymers were poly(acrylamide-co-n-butyl methacrylate (BMA)), poly-(N-vinylpyrroridone-co-BMA), poly(acrylamide-2-methylpropanesulfonic acid-co-BMA) and poly(2-methacryloyloxyethyl phosphorylcholine(MPC)-co-BMA). The amount of adhered platelets depends on the structure of the hydrophilic group in the copolymers. The surface of beads coated with poly(MPC-co-BMA) suppressed the adherence of platelets.

引用

页码：289 / 294

页数：6

共 15 条

[1]

ANDRADE JD, 1973, T AM SOC ART INT ORG, V19, P1

[2]

FISCHER JP, 1979, J POLYM SCI POLYM S, V66, P443

[3]

Holly F.J., 1979, J POLYM SCI PS, V66, P409

[4] REDUCED THROMBOGENICITY OF POLYMERS HAVING PHOSPHOLIPID POLAR GROUPS [J].