ENANTIOSELECTIVE TRANSESTERIFICATIONS OF 2-METHYL-1-ALCOHOLS CATALYZED BY LIPASES FROM PSEUDOMONAS

被引：20

作者：

NORDIN, O ^{[1
]}

HEDENSTROM, E ^{[1
]}

HOGBERG, HE ^{[1
]}

机构：

[1] MID SWEDEN UNIV,DEPT SCI & ENGN,S-85170 SUNDSVALL,SWEDEN

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(00)86227-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Racemic beta-methyl-2-thiophenepropanol was resolved (E approximate to 200) via transesterification catalysed by lipase from Pseudomonas fluorescens using an excess of vinyl acetate in chloroform at an initial water activity: a(W) = 0.32. When trying to resolve rac-2-methyl-1-alkanols more modest E-values were obtained (E approximate to 10) and were of the same order of magnitude irrespective of substrate chainlength, water activity, immobilization, acyl donor or other Pseudomonas derived lipases. However, the reaction rates are affected by variations of these parameters. Both the rates and E-values were influenced by the nature of the solvent.

引用

页码：785 / 788

页数：4

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