A NEW APPROACH TO THE SYNTHESIS OF THE CC-1065 DUOCARMYCIN PHARMACOPHORE

被引：49

作者：

TIDWELL, JH ^{[1
]}

BUCHWALD, SL ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 24期

关键词：

D O I：

10.1021/jo00050a003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The spirocyclic 1,2,7,7a-tetrahydrocycloprop-[1,2-c]indol-4-one subunit of CC-1065 and duocarmycin A, which comprises the common pharmacophore of the two antibiotics, has been efficiently synthesized in six steps from readily available starting materials. The key step of the synthesis utilizes a zirconocene-stabilized benzyne complex.

引用

页码：6380 / 6382

页数：3

共 37 条

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