STRUCTURE-ACTIVITY-RELATIONSHIPS IN AN IMIDAZOLE-BASED SERIES OF THROMBOXANE SYNTHASE INHIBITORS

被引:22
作者
MANLEY, PW
ALLANSON, NM
BOOTH, RFG
BUCKLE, PE
KUZNIAR, EJ
LAD, N
LAI, SMF
LUNT, DO
TUFFIN, DP
机构
[1] SEARLE RES & DEV,DEPT MED CHEM,HIGH WYCOMBE HP12 4HL,BUCKS,ENGLAND
[2] SEARLE RES & DEV,DEPT BIOL,HIGH WYCOMBE HP12 4HL,BUCKS,ENGLAND
关键词
D O I
10.1021/jm00392a011
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1588 / 1595
页数:8
相关论文
共 24 条
  • [1] CGS-12970 - A NOVEL, LONG-ACTING THROMBOXANE SYNTHETASE INHIBITOR
    AMBLER, J
    BUTLER, KD
    KU, EC
    MAGUIRE, ED
    SMITH, JR
    WALLIS, RB
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1985, 86 (02) : 497 - 504
  • [2] SYNTHESIS OF THROMBOXANE-A2
    BHAGWAT, SS
    HAMANN, PR
    STILL, WC
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (22) : 6372 - 6376
  • [4] SELECTIVE THROMBOXANE SYNTHETASE INHIBITORS .2. 3-(1H-IMIDAZOL-1-YLMETHYL)-2-METHYL-1H-INDOLE-1-PROPANOIC ACID AND ANALOGS
    CROSS, PE
    DICKINSON, RP
    PARRY, MJ
    RANDALL, MJ
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (03) : 342 - 346
  • [5] SELECTIVE THROMBOXANE SYNTHETASE INHIBITORS .1. 1-[(ARYLOXY)ALKYL]-1H-IMIDAZOLES
    CROSS, PE
    DICKINSON, RP
    PARRY, MJ
    RANDALL, MJ
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (10) : 1427 - 1432
  • [6] IMIDAZO[1,5-A]PYRIDINES - A NEW CLASS OF THROMBOXANE-A2 SYNTHETASE INHIBITORS
    FORD, NF
    BROWNE, LJ
    CAMPBELL, T
    GEMENDEN, C
    GOLDSTEIN, R
    GUDE, C
    WASLEY, JWF
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (02) : 164 - 170
  • [7] INHIBITION OF PLATELET THROMBOXANE-A2 SYNTHASE ACTIVITY BY SODIUM 5-(3'-PYRIDINYLMETHYL)BENZOFURAN-2-CARBOXYLATE
    GORMAN, RR
    JOHNSON, RA
    SPILMAN, CH
    AIKEN, JW
    [J]. PROSTAGLANDINS, 1983, 26 (02): : 325 - 342
  • [8] ARTERIAL-WALLS ARE PROTECTED AGAINST DEPOSITION OF PLATELET THROMBI BY A SUBSTANCE (PROSTAGLANDIN-X) WHICH THEY MAKE FROM PROSTAGLANDIN ENDOPEROXIDES
    GRYGLEWSKI, RJ
    BUNTING, S
    MONCADA, S
    FLOWER, RJ
    VANE, JR
    [J]. PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1976, 12 (05) : 685 - 713
  • [9] THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES
    HAMBERG, M
    SVENSSON, J
    SAMUELSSON, B
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) : 2994 - 2998
  • [10] SUBSTITUENT CONSTANTS FOR CORRELATION ANALYSIS
    HANSCH, C
    ROCKWELL, SD
    JOW, PYC
    LEO, A
    STELLER, EE
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (02) : 304 - 306