The scope of antibody catalysis

被引：16

作者：

Jacobsen, JR

Schultz, PG

机构：

[1] Department of Chemistry, University of California at Berkeley, Berkeley

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 06期

关键词：

D O I：

10.1016/0959-440X(95)80016-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New strategies for hapten design have fed to antibodies that catalyze reactions by increasingly complex mechanisms and with large increases in catalytic rate. Rational design has also been used to elicit catalytic antibodies for difficult chemical transformations as well as reactions for which no enzyme is known. These experiments have demonstrated the chemical potential of large combinatorial libraries that have been given appropriate mechanistic instruction.

引用

收藏

页码：818 / 824

页数：7

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