BASE TRANSITIONS AND BASE TRANSVERSIONS SEEN IN MUTATIONS AMONG VARIOUS TYPES OF THE HEPATITIS-C VIRAL GENOME

被引：7

作者：

TANAKA, T ^{[1
]}

KATO, N ^{[1
]}

HIJIKATA, M ^{[1
]}

SHIMOTOHNO, K ^{[1
]}

机构：

[1] NATL CANC CTR,RES INST,DIV VIROL,TSUKIJI 5-1-1,CHUO KU,TOKYO 104,JAPAN

来源：

FEBS LETTERS | 1993年 / 315卷 / 02期

关键词：

HEPATITIS-C VIRUS; GENOTYPE; MUTATION; BASE TRANSITION; BASE TRANSVERSION; MULTIPLE BASE SUBSTITUTION;

D O I：

10.1016/0014-5793(93)81163-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We counted base transitions (Ts) and transversions (Tv) in mutations among various types of hepatitis C virus (HCV) sequences. The Ts/Tv ratio was useful for distinguishing the (geno)type of the compared HCV sequences, since the ratio was 4.0 or more among sequences of the same type, while it was less than 2.0 among sequences of different types. This observation reflects the evolutionary pathway of HCV in which Tv accumulate among distant genomes by mechanisms including multiple base substitutions.

引用

页码：201 / 203

页数：3

共 11 条

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