BREAKDOWN OF INDOLE ALKALOIDS IN SUSPENSION-CULTURES OF TABERNAEMONTANA-DIVARICATA AND CATHARANTHUS-ROSEUS

被引：10

作者：

SCHRIPSEMA, J

DAGNINO, D

DOSSANTOS, RI

VERPOORTE, R

机构：

[1] Leiden/Amsterdam Center for Drug Research, Division of Pharmacognosy, Center for Bio-Pharmaceutical Sciences, Leiden University, Gorlaeus Laboratories, Leiden, 2300 RA

来源：

PLANT CELL TISSUE AND ORGAN CULTURE | 1994年 / 38卷 / 2-3期

关键词：

BREAKDOWN; INDOLE ALKALOIDS; SUSPENSION CULTURE; CATHARANTHUS; TABERNAEMONTANA;

D O I：

10.1007/BF00033890

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The relative importance of breakdown on the accumulation of indole alkaloids has been determined in suspension cultures of Tabernaemontana divaricata and Catharanthus roseus by the feeding of stable isotope labelled alkaloids. In all cultures a considerable amount of the alkaloid biosynthesized was broken down. The breakdown was found to be dependent on the culture period and the half-life was in the order of several days. The breakdown could not explain the difference between producing and non-producing cultures. Further it was determined that in both cultures the breakdown was due to both biotic and abiotic factors.

引用

页码：299 / 305

页数：7

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