HUMAN ELONGATION FACTOR-EF-1-BETA - CLONING AND CHARACTERIZATION OF THE EF1-BETA-5A GENE AND ASSIGNMENT OF EF-1-BETA ISOFORMS TO CHROMOSOME-2, CHROMOSOME-5, CHROMOSOME-15 AND CHROMOSOME-X

被引：25

作者：

PIZZUTI, A

GENNARELLI, M

NOVELLI, G

COLOSIMO, A

LOCICERO, S

CASKEY, CT

DALLAPICCOLA, B

机构：

[1] BAYLOR COLL MED, INST MOLEC GENET, HOUSTON, TX 77030 USA

[2] BAYLOR COLL MED, HOWARD HUGHES MED INST, HOUSTON, TX 77030 USA

[3] TOR VERGATA UNIV ROME, DEPT PUBL HLTH & CELL BIOL, ROME, ITALY

[4] UNIV CATTOLICA SACRO CUORE, CHAIR HUMAN GENET, I-00168 ROME, ITALY

[5] CSS HOSP IRCCS, SAN GIOVANNI ROTONDO, ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.2454

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here the isolation and characterization of a novel human elongation factor-1 β (EF-1β) gene by cDNA selection from YAC mapping on chromosome 5q12-q14. This gene is specifically transcribed in fetal brain and in skeletal muscle and is characterized by a complete sequence homology with previously described EF-1β cDNAs. We also assigned the loci for three other EF-1β isoforms, to human chromosomes 2, 15 and X. The multiple chromosomal assignments of EF-1β loci demontrates the genetic heterogeneity of human EF-1β peptides. © 1993 Academic Press.

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收藏

页码：154 / 162

页数：9

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