RIBOZYMES - BIOLOGY, BIOCHEMISTRY, AND IMPLICATIONS FOR CLINICAL MEDICINE

被引：22

作者：

KIEHNTOPF, M

ESQUIVEL, EL

BRACH, MA

HERRMANN, F

机构：

[1] FREE UNIV BERLIN, KLINIKUM RUDOLF VIRCHOW, DEPT MED ONCOL & APPL MOLEC BIOL, D-13122 BERLIN, GERMANY

[2] MAX DELBRUCK CTR MOLEC MED, D-13122 BERLIN, GERMANY

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1995年 / 73卷 / 02期

关键词：

RIBOZYMES; CATALYTIC RNA; GENE THERAPY;

D O I：

10.1007/BF00270579

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ribozymes are a class of ribonucleic acid (RNA) molecules that possess enzymatic properties. Upon binding to complementary nucleic acid strands, catalytic degradation takes place via a cleavage reaction. In effect, inactivation of susceptible substrate RNA molecules takes place at a catalytic rate and with a high degree of substrate specificity. This article reviews the biology and biochemistry of this class of molecules and its potential applications in clinical medicine.

引用

页码：65 / 71

页数：7

共 59 条

[11] STRUCTURAL AND IONIC REQUIREMENTS FOR SELF-CLEAVAGE OF VIRUSOID RNAS AND TRANS SELF-CLEAVAGE OF VIROID RNA [J].