THE SYNTHESIS OF (-)-4-METHYL-8-CHLORO-TRANS-1,2,3,4,4A,5,6,10B-OCTAHYDROBENZO-[F]-QUINOLIN-3-ONE-[3-C-14] (LY300502-C-14]) VIA A CIRCUITOUS ROUTE

被引：2

作者：

KUO, FJ ^{[1
]}

WHEELER, WJ ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS,INDIANAPOLIS,IN 46285

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 10期

关键词：

SELECTIVE TYPE I 5-ALPHA-REDUCTASE INHIBITOR; LY300502; CARBON; 14;

D O I：

10.1002/jlcr.2580341004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of the C-14 labeled isotopomer of LY300502, a potent 5 alpha-reductase inhibitor has been accomplished in four radiochemical steps. The route involves the synthesis of LY300502-[C-14] from LY300502 via a circuitous route; the label was introduced with ethyl chloroformate-[carbonyl-C-14]

引用

页码：915 / 920

页数：6

共 10 条

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