CORRELATION ANALYSIS OF BAKERS STUDIES ON ENZYME INHIBITION .2. CHYMOTRYPSIN, TRYPSIN, THYMIDINE PHOSPHORYLASE, URIDINE PHOSPHORYLASE, THYMIDYLATE SYNTHETASE, CYTOSINE NUCLEOSIDE DEAMINASE, DIHYDROFOLATE-REDUCTASE, MALATE DEHYDROGENASE, GLUTAMATE-DEHYDROGENASE, LACTATE-DEHYDROGENASE, AND GLYCERALDEHYDE-PHOSPHATE DEHYDROGENASE

被引：60

作者：

YOSHIMOTO, M ^{[1
]}

HANSCH, C ^{[1
]}

机构：

[1] POMONA COLL,DEPT CHEM,CLAREMONT,CA 91711

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1976年 / 19卷 / 01期

关键词：

D O I：

10.1021/jm00223a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：71 / 98

页数：28

共 69 条

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BAKER, BR ;

KELLEY, JL .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (06) :1039-&

[42] IRREVERSIBLE ENZYME INHIBITORS .183. PROTEOLYTIC ENZYMES .18. INHIBITORS OF GUINEA PIG COMPLEMENT DERIVED BY QUATERNIZATION OF PHENYLALKYLPYRIDINES WITH ALPHA-BROMOMETHYLBENZENESULFONYL FLUORIDES [J].

BAKER, BR ;

DOLL, MH .

JOURNAL OF MEDICINAL CHEMISTRY, 1971, 14 (09) :793-&

[43] IRREVERSIBLE ENZYME INHIBITORS 99 - INHIBITORS OF THYMIDINE PHOSPHORYLASE .7. FURTHER STUDIES ON HYDROPHOBIC BONDING WITH HYDROCARBON SUBSTITUENTS ON ACIDIC URACILS [J].

BAKER, BR ;

KAWAZU, M ;

MCCLURE, JD .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1967, 56 (09) :1081-&

[44] IRREVERSIBLE ENZYME-INHIBITORS .192. HYDROPHOBIC BONDING TO SOME DEHYDROGENASES WITH 5-SUBSTITUTED-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACIDS [J].

BAKER, BR ;

BRAMHALL, RR .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (03) :237-&

[45] IRREVERSIBLE ENZYME-INHIBITORS .191. HYDROPHOBIC BONDING TO SOME DEHYDROGENASES BY 6-SUBSTITUTED, 7-SUBSTITUTED, OR 8-SUBSTITUTED-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACIDS [J].

BAKER, BR ;

BRAMHALL, RR .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (03) :235-&

[46] ANALOGS OF TETRAHYDROFOLIC ACID .17. ON MODE OF BINDING OF P-AMINOBENZOYL MOIETY OF N-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYLPROPYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID TO DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

JORDAAN, JH .

JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (01) :35-&

[47] IRREVERSIBLE ENZYME INHIBITORS .76. INHIBITORS OF THYMIDINE PHOSPHORYLASE .2. HYDROPHOBIC BONDING BY 1-SUBSTITUTED URACILS [J].

BAKER, BR ;

KAWAZU, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (03) :302-&

[48] IRREVERSIBLE ENZYME INHIBITORS .106. PROTEOLYTIC ENZYMES .I. BULK TOLERANCES IN TRYPSIN-INHIBITOR COMPLEXES [J].

BAKER, BR ;

ERICKSON, EH .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) :1123-+

[49] IRREVERSIBLE ENZYME INHIBITORS .169. INHIBITION OF FUDR PHOSPHORYLASE FROM WALKER-256 RAT TUMOR BY 6-SUBSTITUTED URACILS [J].

BAKER, BR ;

KELLEY, JL .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (03) :456-&

[50]

BAKER BR, 1967, DESIGN ACTIVE SITE D, P79

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