SYNTHESIS OF BENZOCHLORIN IMINIUM SALTS WITH IMPROVED PHOTOSENSITIZING PROPERTIES

被引:10
作者
MORGAN, AR [1 ]
GUPTA, S [1 ]
机构
[1] UNIV TOLEDO,DEPT MED,TOLEDO,OH 43606
关键词
D O I
10.1016/S0040-4039(00)73496-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Treatment of a nickel benzochlorin iminium salt with conc. sulfuric acid generates the free base analogs and their sulfonated derivatives. Insertion of zinc lead to the formation of metallobenzochlorins with improved photodynamic activities.
引用
收藏
页码:5347 / 5350
页数:4
相关论文
共 7 条
[1]   WITTIG CONDENSATION PRODUCTS FROM NICKEL MESO-FORMYL-OCTAETHYLPORPHYRIN AND MESO-FORMYL-AETIOPORPHYRIN-I AND SOME CYCLIZATION REACTIONS [J].
ARNOLD, DP ;
GAETEHOLMES, R ;
JOHNSON, AW ;
SMITH, ARP ;
WILLIAMS, GA .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1978, (12) :1660-1670
[2]   IMINIUM SALT OF COPPER BENZOCHLORIN (CDS1), A NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY - MECHANISM OF CELL-KILLING [J].
HAMPTON, JA ;
SKALKOS, D ;
TAYLOR, PM ;
SELMAN, SH .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1993, 58 (01) :100-105
[3]  
KESSEL D, COMMUNICATION
[4]   OBSERVATIONS ON THE SYNTHESIS AND INVIVO PHOTODYNAMIC ACTIVITY OF SOME BENZOCHLORINS [J].
MORGAN, AR ;
SKALKOS, D ;
MAGUIRE, G ;
RAMPERSAUD, A ;
GARBO, G ;
KECK, R ;
SELMAN, SH .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1992, 55 (01) :133-136
[5]   COPPER BENZOCHLORIN, A NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY - EFFECTS ON A TRANSPLANTABLE UROTHELIAL TUMOR [J].
SELMAN, SH ;
HAMPTON, JA ;
MORGAN, AR ;
KECK, RW ;
BALKANY, AD ;
SKALKOS, D .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1993, 57 (04) :681-685
[6]   IMINIUM SALT BENZOCHLORINS - STRUCTURE-ACTIVITY RELATIONSHIP STUDIES [J].
SKALKOS, D ;
HAMPTON, JA ;
KECK, RW ;
WAGONER, M ;
SELMAN, SH .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1994, 59 (02) :175-181
[7]   VILSMEIER REACTIONS OF PORPHYRINS AND CHLORINS WITH 3-(DIMETHYLAMINO)ACROLEIN TO GIVE MESO-(2-FORMYLVINYL)PORPHYRINS - NEW SYNTHESES OF BENZOCHLORINS, BENZOISOBACTERIOCHLORINS, AND BENZOBACTERIOCHLORINS AND REDUCTIVE COUPLING OF PORPHYRINS AND CHLORINS USING LOW-VALENT TITANIUM COMPLEXES [J].
VICENTE, MGH ;
SMITH, KM .
JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (14) :4407-4418