GENETICALLY ENGINEERED SYNTHESIS OF COMPLEX NATURAL-PRODUCTS

被引：21

作者：

SCOTT, AI

机构：

[1] Center for Biological Nuclear Magnetic Resonance, Department of Chemistry Texas A, M University, College Station

来源：

TETRAHEDRON | 1992年 / 48卷 / 13期

关键词：

D O I：

10.1016/S0040-4020(01)88521-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The feasibility of multi-enzyme, one-flask total synthesis of natural products is demonstrated by the preparation of a tetramethyl corphinoid structure and of the alkaloid strictosidine by gene transfer and overexpression of the corresponding gene products in E. coli.

引用

页码：2559 / 2578

页数：20

共 61 条

[11] CLONING AND ANALYSIS OF GENES INVOLVED IN COENZYME-B12 BIOSYNTHESIS IN PSEUDOMONAS-DENITRIFICANS [J].

CAMERON, B ;

BRIGGS, K ;

PRIDMORE, S ;

BREFORT, G ;

CROUZET, J .

JOURNAL OF BACTERIOLOGY, 1989, 171 (01) :547-557

[12]

COURZET J, 1990, CHEM ASPECTS ENZYME, P299

[13] UROPORPHYRINOGEN-III SYNTHASE - STUDIES ON ITS MECHANISM OF ACTION, MOLECULAR-BIOLOGY AND BIOCHEMISTRY [J].

CROCKETT, N ;

ALEFOUNDER, PR ;

BATTERSBY, AR ;

ABELL, C .

TETRAHEDRON, 1991, 47 (31) :6003-6014

[14] VITAMIN-B12 - EXPERIMENTS CONCERNING THE ORIGIN OF ITS MOLECULAR-STRUCTURE [J].

ESCHENMOSER, A .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1988, 27 (01) :5-39

[15] BIOSYNTHESIS OF PORPHYRINS AND CORRINS .2. ISOLATION, PURIFICATION, AND NMR INVESTIGATIONS OF THE PORPHOBILINOGEN-DEAMINASE COVALENT COMPLEX [J].

EVANS, JNS ;

BURTON, G ;

FAGERNESS, PE ;

MACKENZIE, NE ;

SCOTT, AI .

BIOCHEMISTRY, 1986, 25 (04) :905-912

[16] BIOSYNTHESIS OF THE NATURAL PORPHYRINS - PROOF THAT HYDROXYMETHYLBILANE SYNTHASE (PORPHOBILINOGEN DEAMINASE) USES A NOVEL BINDING GROUP IN ITS CATALYTIC ACTION [J].

HART, GJ ;

MILLER, AD ;

LEEPER, FJ ;

BATTERSBY, AR .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (23) :1762-1764

[17] EVIDENCE THAT THE PYRROMETHANE COFACTOR OF HYDROXYMETHYLBILANE SYNTHASE (PORPHOBILINOGEN DEAMINASE) IS BOUND THROUGH THE SULFUR ATOM OF A CYSTEINE RESIDUE [J].

HART, GJ ;

MILLER, AD ;

BATTERSBY, AR .

BIOCHEMICAL JOURNAL, 1988, 252 (03) :909-912

[18] COBALAMIN (VITAMIN-B12) BIOSYNTHETIC GENES OF SALMONELLA-TYPHIMURIUM [J].

JETER, RM ;

ROTH, JR .

JOURNAL OF BACTERIOLOGY, 1987, 169 (07) :3189-3198

[19] PRE-UROPORPHYRINOGEN - SUBSTRATE FOR UROPORPHYRINOGEN-III COSYNTHETASE [J].

JORDAN, PM ;

BURTON, G ;

NORDLOV, H ;

SCHNEIDER, MM ;

PRYDE, L ;

SCOTT, AI .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1979, (05) :204-205

[20] MECHANISM OF ACTION OF PORPHOBILINOGEN DEAMINASE - THE PARTICIPATION OF STABLE ENZYME SUBSTRATE COVALENT INTERMEDIATES BETWEEN PORPHOBILINOGEN AND THE PORPHOBILINOGEN DEAMINASE FROM RHODOPSEUDOMONAS-SPHEROIDES [J].

JORDAN, PM ;

BERRY, A .

BIOCHEMICAL JOURNAL, 1981, 195 (01) :177-181

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