FORMATION OF FLUORESCENT PYRAZINE DERIVATIVES VIA A NOVEL DEGRADATION PATHWAY OF THE CARBACEPHALOSPORIN LORACARBEF

被引：2

作者：

BAERTSCHI, SW

DORMAN, DE

SPANGLE, LA

COLLINS, MW

LORENZ, LJ

机构：

[1] Eli Lilly and Company, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1995年 / 13卷 / 03期

关键词：

CEPHALOSPORIN DEGRADATION; CARBACEPHALOSPORINS; LORACEBEF; CEFACLOR; FLUORESCENT; PYRAZINE; ISOLATION; STABILITY STRESS TESTING; STRUCTURE ELUCIDATION;

D O I：

10.1016/0731-7085(95)01255-J

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

[No abstract available]

引用

页码：323 / 328

页数：6

共 8 条

[1] ISOLATION AND STRUCTURE ELUCIDATION OF A NOVEL PRODUCT OF THE ACIDIC DEGRADATION OF CEFACLOR [J].

BAERTSCHI, SW ;

DORMAN, DE ;

OCCOLOWITZ, JL ;

SPANGLE, LA ;

COLLINS, MW ;

WILDFEUER, ME ;

LORENZ, LJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1993, 82 (06) :622-626

[2] ISOLATION AND IDENTIFICATION OF FLUORESCENT DEGRADATION PRODUCT OF SOME BETA-LACTAM ANTIBIOTICS [J].

BARBHAIYA, RH ;

BROWN, RC ;

PAYLING, DW ;

TURNER, P .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1978, 30 (04) :224-227

[3] APPLICATIONS OF ARTIFICIAL-INTELLIGENCE FOR CHEMICAL INFERENCE .37. GENOA - A COMPUTER-PROGRAM FOR STRUCTURE ELUCIDATION UTILIZING OVERLAPPING AND ALTERNATIVE SUBSTRUCTURES [J].

CARHART, RE ;

SMITH, DH ;

GRAY, NAB ;

NOURSE, JG ;

DJERASSI, C .

JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (08) :1708-1718

[4] 2-HYDROXY-3-ARYL-6-METHYLPYRAZINES - FLUOROPHORES FORMED FROM THE REACTION OF FORMALDEHYDE WITH CYCLIC ENAMINE DEGRADATION PRODUCTS COMMON TO BETA-LACTAM ANTIBIOTICS WITH ARYL GLYCINE SIDE-CHAINS [J].

INDELICATO, JM ;

DORMAN, DE ;

ENGEL, GL .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1981, 33 (02) :119-121

[5] ISOLATION AND IDENTIFICATION OF A FLUOROPHORE FROM AMPICILLIN DEGRADATION [J].

LEBELLE, MJ ;

VILIM, A ;

WILSON, WL .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1979, 31 (07) :441-443

[6] AQUEOUS ACIDIC DEGRADATION OF THE CARBACEPHALOSPORIN LORACARBEF [J].

SKIBIC, MJ ;

TAYLOR, KW ;

OCCOLOWITZ, JL ;

COLLINS, MW ;

PASCHAL, JW ;

LORENZ, LJ ;

SPANGLE, LA ;

DORMAN, DE ;

BAERTSCHI, SW .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1993, 82 (10) :1010-1017

[7]

UNO T, 1981, CHEM PHARM BULL, V29, P1344

[8]

1994, MAR INT C HARM ICH P

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