A NEW SYNTHESIS OF SOME 4'-THIO-(D)UNDER-BAR-RIBONUCLEOSIDES AND PRELIMINARY ENZYMATIC EVALUATION

被引：31

作者：

LEYDIER, C ^{[1
]}

BELLON, L ^{[1
]}

BARASCUT, JL ^{[1
]}

DEYDIER, J ^{[1
]}

MAURY, G ^{[1
]}

PELICANO, H ^{[1
]}

ELALAOUI, MA ^{[1
]}

IMBACH, JL ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,CNRS,URA 488,F-34095 MONTPELLIER 5,FRANCE

来源：

NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 10期

关键词：

D O I：

10.1080/15257779408013205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new synthesis of 4'-thioribonucleosides is presented together with the enzymatic evaluation of the adenosine analogues with respect to adenosine kinase. The 4-thio-D-ribofuranosyl carbohydrate precursor ($) under bar 7 was obtained in good yield from D-ribose and further reacted with adenine and cytosine to give the a and beta anomers of 4'-thioadenosine and 4'-thiocytidine, respectively. 4'-thio-beta-($) under bar D-adenosine, ($) under bar 12 beta, is a poor substrate for bovine liver adenosine kinase but does not show substrate inhibition of the enzyme.

引用

页码：2035 / 2050

页数：16

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