IDENTIFICATION AND CHROMOSOMAL MAPPING OF A 3RD MOUSE RUNT-LIKE LOCUS

被引：13

作者：

CALABI, F

RHODES, M

WILLIAMSON, P

BOYD, Y

机构：

[1] HGMP RESOURCE CTR,HINXTON CB10 1RQ,CAMBS,ENGLAND

[2] MRC,RADIOBIOL UNIT,DIDCOT OX11 0RD,OXON,ENGLAND

来源：

GENOMICS | 1995年 / 26卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0888-7543(95)80184-N

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Drosophila runt gene, which controls early events in embryogenesis, has been shown to have homologues in human and mouse. The human gene on 21q22 is involved in the t(8;21) associated with acute myeloid leukemia. Two mouse runt-like loci encoding DNA-binding proteins have been identified. We report here the isolation and partial sequence of a molecular clone of a third mouse runt-like locus. By using a panel of somatic cell hybrids and interspecific backcross mice, we map the novel locus to the telomeric region Of mouse chromosome 4. (C) 1995 Academic Press, Inc.

引用

页码：607 / 610

页数：4

共 21 条

[11] T(8-21) BREAKPOINTS ON CHROMOSOME-21 IN ACUTE MYELOID-LEUKEMIA ARE CLUSTERED WITHIN A LIMITED REGION OF A SINGLE GENE, AML1 [J].