IDENTIFICATION OF CIS-3'-HYDROXYCOTININE AS A URINARY NICOTINE METABOLITE

被引：14

作者：

VONCKEN, P

RUSTEMEIER, K

SCHEPERS, G

机构：

[1] INBIFO Institut für biologische Forschung, D-5000, Körln 90

来源：

XENOBIOTICA | 1990年 / 20卷 / 12期

关键词：

D O I：

10.3109/00498259009046633

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. cis-3'-Hydroxycotinine was detected as an S(-)-nicotine metabolite in the urine of smokers as well as in the urine of rats and hamsters dosed with nicotine. 2. The excreted amount of cis-3'-hydroxycotinine is lower than that of the trans-isomer. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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页码：1353 / 1356

页数：4

相关论文

共 11 条

[1]

BARLOW RD, 1987, J CHROMATOGR-BIOMED, V419, P375

[2]

BOWMAN ER, 1962, J PHARMACOL EXP THER, V135, P306

[3] STRUCTURE OF HYDROXYCOTININE, A NICOTINE METABOLITE [J].

DAGNE, E ;

CASTAGNOLI, N .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (04) :356-+

[4] RECENT STUDIES OF NICOTINE METABOLISM IN HUMANS [J].

JACOB, P ;

BENOWITZ, NL ;

SHULGIN, AT .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 30 (01) :249-253

[5] DEMETHYLATION OF COTININE INVIVO [J].

MCKENNIS, H ;

TURNBULL, LB ;

BOWMAN, ER ;

WADA, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1959, 81 (15) :3951-3954

[6]

MCKENNIS H, 1962, J BIOL CHEM, V237, P541

[7] TRANS-3'-HYDROXYCOTININE AS A MAIN METABOLITE IN URINE OF SMOKERS [J].

NEURATH, GB ;

DUNGER, M ;

ORTH, D ;

PEIN, FG .

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 1987, 59 (02) :199-201

[8] SPECIES VARIATION AND STEREOSELECTIVITY IN THE METABOLISM OF NICOTINE ENANTIOMERS [J].

NWOSU, CG ;

CROOKS, PA .

XENOBIOTICA, 1988, 18 (12) :1361-1372

[9] DETERMINATION OF CIS-3-HYDROXYCOTININE AND TRANS-3-HYDROXYCOTININE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

ODOHERTY, S ;

REVANS, A ;

SMITH, CL ;

MCBRIDE, M ;

COOKE, M .

JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY & CHROMATOGRAPHY COMMUNICATIONS, 1988, 11 (10) :723-725

[10]

VALA EK, 1990, 4TH EUR C BIOPH PHAR