INFLUENCE OF ACTIVE MUSCLE MASS ON GLUCOSE-HOMEOSTASIS DURING EXERCISE IN HUMANS

被引:94
作者
KJAER, M
KIENS, B
HARGREAVES, M
RICHTER, EA
机构
[1] UNIV COPENHAGEN,AUGUST KROGH INST,DK-2100 COPENHAGEN,DENMARK
[2] UNIV COPENHAGEN,RIGSHOSP,DEPT MED PHYSIOL B,DK-2200 COPENHAGEN,DENMARK
[3] UNIV COPENHAGEN,RIGSHOSP,DEPT INTERNAL MED TTA,DK-2200 COPENHAGEN,DENMARK
关键词
EPINEPHRINE; NOREPINEPHRINE; HEPATIC GLUCOSE PRODUCTION; GLUCOSE UPTAKE; GLUCOSE CLEARANCE; INSULIN; BLOOD FLOW; METABOLISM; LACTATE;
D O I
10.1152/jappl.1991.71.2.552
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To study the effect of increasing amounts of exercising muscle mass on the relationship between glucose mobilization and peripheral glucose uptake, seven young men (23-28 yr) bicycled for 70 min at a work load of 55-60% VO2max. From minute 30 to 50, arm cranking was added and total work load increased to 82 +/- 4% VO2max. During leg exercise, hepatic glucose production (Ra) increased in parallel with peripheral glucose uptake (Rd) and euglycemia was maintained. During arm + leg exercise, Ra increased more than Rd and accordingly plasma glucose increased from 5.11 +/- 0.22 to 8.00 +/- 0.66 mmol/1 (P < 0.05). Plasma catecholamines increased three- to four-fold more during arm + leg exercise than during leg exercise. Leg glucose uptake increased with time regardless of arm cranking. Net leg lactate release during leg exercise was reverted to a net leg lactate uptake during arm + leg exercise. The rate of glycogen breakdown in exercising leg muscle was not altered by addition of arm cranking. In conclusion, when large amounts of muscle mass are active, plasma catecholamines increase sharply and mobilization of glucose exceeds peripheral glucose uptake. This indicates that mechanisms other than feedback regulation to maintain euglycemia are involved in hormonal and substrate mobilization during intense exercise in humans.
引用
收藏
页码:552 / 557
页数:6
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