MEMORY IMPAIRMENTS INDUCED BY PERIPHERALLY ADMINISTERED CHOLECYSTOKININ A-TYPE RECEPTOR ANTAGONISTS IN RATS

被引：18

作者：

ITOH, S

TAKASHIMA, A

MAEDA, Y

机构：

[1] Shionogi Research Laboratories, Osaka, Fukushima-ku

来源：

DRUG DEVELOPMENT RESEARCH | 1992年 / 26卷 / 01期

关键词：

CCK ANTAGONIST; PASSIVE AVOIDANCE RESPONSE; ACTIVE AVOIDANCE RESPONSE; MORRIS WATER POOL TEST; MEMORY;

D O I：

10.1002/ddr.430260108

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Intraperitoneal injection of cholecystokinin (CCK) A-type receptor antagonists, L-364,718 and CR 1409, caused dose-dependent memory impairments in passive and active avoidance responses and in Morris water pool test in rats. These antagonist effects were significant at a dose of 1 mg/kg, while with proglumide, 50-100 mg/kg were required to produce a similar memory deficit. The results suggest that loss of biologically active CCK octapeptide (CCK-8), not only in the brain but also in the peripheral tissues, causes memory impairments in rats.

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页码：89 / 99

页数：11

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