ANTINOCICEPTIVE EFFECT OF TAURINE AND ITS INHIBITION BY NAXOLONE

被引：23

作者：

SERRANO, JS ^{[1
]}

SERRANO, MI ^{[1
]}

GUERRERO, MR ^{[1
]}

RUIZ, R ^{[1
]}

POLO, J ^{[1
]}

机构：

[1] UNIV SEVILLE,SCH MED,DEPT BIOSTAT,E-41009 SEVILLE,SPAIN

来源：

GENERAL PHARMACOLOGY | 1990年 / 21卷 / 03期

关键词：

D O I：

10.1016/0306-3623(90)90833-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. 1. We have tested the effect of taurine on nociceptive stimulation provoked by chemical agent (acetic acid) and by the hot-plate test. 2. 2. In the acetic acid test, taurine exerts an antinociceptive effect at every dose and time assayed. The observed effect was dose-related. 3. 3. Naxolone pretreatment antagonizes the antinociceptive effect of taurine in the acetic acid test. 4. 4. The results obtained in hot-plate test show that taurine did not significantly affect latency time for paw licking. © 1990.

引用

页码：333 / 336

页数：4

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