INFLUENCE OF SALT LOADING ON THE CARDIAC AND RENAL PREPROENDOTHELIN-1 MESSENGER-RNA EXPRESSION IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

被引：19

作者：

FERON, O ^{[1
]}

SALOMONE, S ^{[1
]}

GODFRAIND, T ^{[1
]}

机构：

[1] UNIV CATHOLIQUE LOUVAIN,PHARMACOL LAB,B-1200 BRUSSELS,BELGIUM

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 209卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1484

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelin-1 is a potent vasoactive peptide which may play a role in the regulation of vascular resistance through its autocrine/paracrine effects. We have investigated the influence of salt loading on the renal and cardiac production of endothelin-1 in stroke prone spontaneously hypertensive rats, a classical model of hypertension. The results show that the dietary salt intake did not change systolic blood pressure nor the renal expression of the preproendothelin-1 mRNA but increased cardiac expression of the endothelin-1 gene transcript and a concomitant ventricular hypertrophy. (C) 1995 Academic Press, Inc.

引用

页码：161 / 166

页数：6

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