SYNTHESIS AND IMMUNOMODULATING ACTIVITY OF 1-AMINO-2-THIOHYDANTOIN DERIVATIVES

被引：21

作者：

BLANC, M

CUSSAC, M

BOUCHERLE, A

LECLERC, G

机构：

[1] FAC PHARM LA TRONCHE,CHIM THERAPEUT LAB,PHARMACOCHIM MOL GRP,F38700 LA TRONCHE,FRANCE

[2] FAC PHARM MEYLAN,CHIM ORGAN LAB,PHARMACOCHIM MOLEC GRP,F38240 MEYLAN,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 08期

关键词：

1-AMINO-2-THIOHYDANTOIN; IMMUNOMODULATORS; ANTICANCER AGENTS;

D O I：

10.1016/0223-5234(92)90119-L

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1-Amino-2-thiohydantoin derivatives have been synthesized. Immunomodulating and anticancer activities have been studied. Their activity on the immune system is complex, being either immunodepressive or immunostimulatory according to the doses, or mainly immunostimulatory. These compounds were devoid of any anticancer activity.

引用

页码：839 / 843

页数：5

共 27 条

[1] SYNTHESIS OF 2-THIOHYDANTOIN DERIVATIVES WITH POTENTIAL IMMUNOMODULATING AND ANTICANCER ACTIVITIES [J].