PHOSPHOLIPID BINDING OF ANTIPHOSPHOLIPID ANTIBODIES AND PLACENTAL ANTICOAGULANT PROTEIN

被引：72

作者：

SAMMARITANO, LR ^{[1
]}

GHARAVI, AE ^{[1
]}

SOBERANO, C ^{[1
]}

LEVY, RA ^{[1
]}

LOCKSHIN, MD ^{[1
]}

机构：

[1] NIAMSD, BETHESDA, MD USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 1992年 / 12卷 / 01期

关键词：

ANTIPHOSPHOLIPID ANTIBODY; LUPUS ANTICOAGULANT; PLACENTAL ANTICOAGULANT PROTEIN; LIPOCORTIN; PHOSPHOLIPID BINDING;

D O I：

10.1007/BF00918270

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity in in vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and that in vivo interaction may occur.

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页码：27 / 35

页数：9

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